| Synonym |
| Thai / English name |
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : NeferineType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 5 microlitersDuration : 25 minutesType of interaction : PharmacokineticsInteraction with drug : Phenacetin*/AcetophenetidinDose/Conc.(drug) : -Result : PositiveRemark : The IC50 values of neferine on CYP1A2 was>320 micromolar (>200 micrograms/mL).
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : NeferineType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 5 microlitersDuration : 25 minutesType of interaction : PharmacokineticsInteraction with drug : Dextromethorphan*/Dextromethorfan/DextromorphanDose/Conc.(drug) : -Result : PositiveRemark : The IC50 values of neferine on CYP2D6 was 73.4+/-16.8 micromolar (45.8+/-10.5 micrograms/mL).
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : NeferineType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 5 microlitersDuration : 10 minutesType of interaction : PharmacokineticsInteraction with drug : TestosteroneDose/Conc.(drug) : -Result : PositiveRemark : The IC50 values of neferine on CYP3A4 was 25.1+/-3.5 micromolar (15.7+/-2.1 micrograms/mL).
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : 80% ethanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 10, 50, 100, 200 and 400 micrograms/mL.Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The inhibitory effects of LAE on CYP2C19 isoenzyme wiht IC50 values 77.38 micrograms/mL.Note : - Their Lineweaver-Burk plots and Dixon plots showed that NF, N-NF, and HMA competitively inhibited CYP2D6 activity with Ki values of 1.88, 2.34 and 1.56 micromolars, respectively - Conclusion, lotus leaves exert a potent inhibitory effect on CYP2D6 isoenzyme. - Abbreviation LAE lotus leaf alcoholic extract AF the alkaloid fraction FF the flavonoid fraction NF nuciferine N-NF N-nornuciferine HMA 2-hydroxy-1-methoxyaporphine
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : 80% ethanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 10, 50, 100, 200 and 400 micrograms/mL.Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The inhibitory effects of LAE on CYP2C6 isoenzyme wiht IC50 values 12.05 micrograms/mL.Note : - Their Lineweaver-Burk plots and Dixon plots showed that NF, N-NF, and HMA competitively inhibited CYP2D6 activity with Ki values of 1.88, 2.34 and 1.56 micromolars, respectively - Conclusion, lotus leaves exert a potent inhibitory effect on CYP2D6 isoenzyme. - Abbreviation LAE lotus leaf alcoholic extract AF the alkaloid fraction FF the flavonoid fraction NF nuciferine N-NF N-nornuciferine HMA 2-hydroxy-1-methoxyaporphine
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : 80% ethanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 10, 50, 100, 200 and 400 micrograms/mL.Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The inhibitory effects of LAE on CYP3A4 isoenzyme wiht IC50 values 98.01 micrograms/mL.Note : - Their Lineweaver-Burk plots and Dixon plots showed that NF, N-NF, and HMA competitively inhibited CYP2D6 activity with Ki values of 1.88, 2.34 and 1.56 micromolars, respectively - Conclusion, lotus leaves exert a potent inhibitory effect on CYP2D6 isoenzyme. - Abbreviation LAE lotus leaf alcoholic extract AF the alkaloid fraction FF the flavonoid fraction NF nuciferine N-NF N-nornuciferine HMA 2-hydroxy-1-methoxyaporphine
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : 80% ethanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 10, 50, 100, 200 and 400 micrograms/mL.Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The inhibitory effects of LAE on CYP2E1 isoenzyme wiht IC50 values 61.43 micrograms/mL.Note : - Their Lineweaver-Burk plots and Dixon plots showed that NF, N-NF, and HMA competitively inhibited CYP2D6 activity with Ki values of 1.88, 2.34 and 1.56 micromolars, respectively - Conclusion, lotus leaves exert a potent inhibitory effect on CYP2D6 isoenzyme. - Abbreviation LAE lotus leaf alcoholic extract AF the alkaloid fraction FF the flavonoid fraction NF nuciferine N-NF N-nornuciferine HMA 2-hydroxy-1-methoxyaporphine
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : 80% ethanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 10, 50, 100, 200 and 400 micrograms/mL.Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The inhibitory effects of LAE on CYP2C9 isoenzyme wiht IC50 values 83.46 micrograms/mL.Note : - Their Lineweaver-Burk plots and Dixon plots showed that NF, N-NF, and HMA competitively inhibited CYP2D6 activity with Ki values of 1.88, 2.34 and 1.56 micromolars, respectively - Conclusion, lotus leaves exert a potent inhibitory effect on CYP2D6 isoenzyme. - Abbreviation LAE lotus leaf alcoholic extract AF the alkaloid fraction FF the flavonoid fraction NF nuciferine N-NF N-nornuciferine HMA 2-hydroxy-1-methoxyaporphine
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : alkaloid fraction (AF)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.5-250 micrograms/mL.Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The inhibitory effects of AF on CYP2C19 isoenzyme wiht IC50 values 40.79 micrograms/mL.Note : - Their Lineweaver-Burk plots and Dixon plots showed that NF, N-NF, and HMA competitively inhibited CYP2D6 activity with Ki values of 1.88, 2.34 and 1.56 micromolars, respectively - Conclusion, lotus leaves exert a potent inhibitory effect on CYP2D6 isoenzyme. - Abbreviation LAE lotus leaf alcoholic extract AF the alkaloid fraction FF the flavonoid fraction NF nuciferine N-NF N-nornuciferine HMA 2-hydroxy-1-methoxyaporphine
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : alkaloid fraction (AF)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.5-250 micrograms/mL.Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The inhibitory effects of AF on CYP2D6 isoenzyme wiht IC50 values 0.96 micrograms/mL.Note : - Their Lineweaver-Burk plots and Dixon plots showed that NF, N-NF, and HMA competitively inhibited CYP2D6 activity with Ki values of 1.88, 2.34 and 1.56 micromolars, respectively - Conclusion, lotus leaves exert a potent inhibitory effect on CYP2D6 isoenzyme. - Abbreviation LAE lotus leaf alcoholic extract AF the alkaloid fraction FF the flavonoid fraction NF nuciferine N-NF N-nornuciferine HMA 2-hydroxy-1-methoxyaporphine
