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Part Used : ใบActivity : CYP2E1 INHIBITIONSolvent/Active Compound : 80% ethanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 10, 50, 100, 200 and 400 micrograms/mL.Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The inhibitory effects of LAE on CYP2E1 isoenzyme wiht IC50 values 61.43 micrograms/mL.Note : - Their Lineweaver-Burk plots and Dixon plots showed that NF, N-NF, and HMA competitively inhibited CYP2D6 activity with Ki values of 1.88, 2.34 and 1.56 micromolars, respectively - Conclusion, lotus leaves exert a potent inhibitory effect on CYP2D6 isoenzyme. - Abbreviation LAE lotus leaf alcoholic extract AF the alkaloid fraction FF the flavonoid fraction NF nuciferine N-NF N-nornuciferine HMA 2-hydroxy-1-methoxyaporphine
Part Used : ใบActivity : CYP2E1 INHIBITIONSolvent/Active Compound : alkaloid fraction (AF)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.5-250 micrograms/mL.Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The inhibitory effects of AF on CYP2E1 isoenzyme wiht IC50 values 63.84 micrograms/mL.Note : - Their Lineweaver-Burk plots and Dixon plots showed that NF, N-NF, and HMA competitively inhibited CYP2D6 activity with Ki values of 1.88, 2.34 and 1.56 micromolars, respectively - Conclusion, lotus leaves exert a potent inhibitory effect on CYP2D6 isoenzyme. - Abbreviation LAE lotus leaf alcoholic extract AF the alkaloid fraction FF the flavonoid fraction NF nuciferine N-NF N-nornuciferine HMA 2-hydroxy-1-methoxyaporphine
Part Used : ใบActivity : CYP2E1 INHIBITIONSolvent/Active Compound : flavonoid fraction (FF)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 2-250 micrograms/mL.Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The inhibitory effects of FF on CYP2E1 isoenzyme wiht IC50 values 102.10 micrograms/mL.Note : - Their Lineweaver-Burk plots and Dixon plots showed that NF, N-NF, and HMA competitively inhibited CYP2D6 activity with Ki values of 1.88, 2.34 and 1.56 micromolars, respectively - Conclusion, lotus leaves exert a potent inhibitory effect on CYP2D6 isoenzyme. - Abbreviation LAE lotus leaf alcoholic extract AF the alkaloid fraction FF the flavonoid fraction NF nuciferine N-NF N-nornuciferine HMA 2-hydroxy-1-methoxyaporphine
