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| Thai / English name |
Part Used : เมล็ดActivity : CYP2D6 INHIBITIONSolvent/Active Compound : NeferineType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 5 microlitersDuration : 25 minutesType of interaction : PharmacokineticsInteraction with drug : Dextromethorphan*/Dextromethorfan/DextromorphanDose/Conc.(drug) : -Result : PositiveRemark : The IC50 values of neferine on CYP2D6 was 73.4+/-16.8 micromolar (45.8+/-10.5 micrograms/mL).
Part Used : ใบActivity : CYP2D6 INHIBITIONSolvent/Active Compound : 80% ethanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 10, 50, 100, 200 and 400 micrograms/mL.Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The inhibitory effects of LAE on CYP2C6 isoenzyme wiht IC50 values 12.05 micrograms/mL.Note : - Their Lineweaver-Burk plots and Dixon plots showed that NF, N-NF, and HMA competitively inhibited CYP2D6 activity with Ki values of 1.88, 2.34 and 1.56 micromolars, respectively - Conclusion, lotus leaves exert a potent inhibitory effect on CYP2D6 isoenzyme. - Abbreviation LAE lotus leaf alcoholic extract AF the alkaloid fraction FF the flavonoid fraction NF nuciferine N-NF N-nornuciferine HMA 2-hydroxy-1-methoxyaporphine
Part Used : ใบActivity : CYP2D6 INHIBITIONSolvent/Active Compound : alkaloid fraction (AF)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.5-250 micrograms/mL.Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The inhibitory effects of AF on CYP2D6 isoenzyme wiht IC50 values 0.96 micrograms/mL.Note : - Their Lineweaver-Burk plots and Dixon plots showed that NF, N-NF, and HMA competitively inhibited CYP2D6 activity with Ki values of 1.88, 2.34 and 1.56 micromolars, respectively - Conclusion, lotus leaves exert a potent inhibitory effect on CYP2D6 isoenzyme. - Abbreviation LAE lotus leaf alcoholic extract AF the alkaloid fraction FF the flavonoid fraction NF nuciferine N-NF N-nornuciferine HMA 2-hydroxy-1-methoxyaporphine
Part Used : ใบActivity : CYP2D6 INHIBITIONSolvent/Active Compound : flavonoid fraction (FF)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 2-250 micrograms/mL.Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The inhibitory effects of FF on CYP2D6 isoenzyme wiht IC50 values 139.40 micrograms/mL.Note : - Their Lineweaver-Burk plots and Dixon plots showed that NF, N-NF, and HMA competitively inhibited CYP2D6 activity with Ki values of 1.88, 2.34 and 1.56 micromolars, respectively - Conclusion, lotus leaves exert a potent inhibitory effect on CYP2D6 isoenzyme. - Abbreviation LAE lotus leaf alcoholic extract AF the alkaloid fraction FF the flavonoid fraction NF nuciferine N-NF N-nornuciferine HMA 2-hydroxy-1-methoxyaporphine
Part Used : ใบActivity : CYP2D6 INHIBITIONSolvent/Active Compound : nuciferin (NF)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.5-100 micromolarsDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The inhibitory effects of NF on CYP2D6 isoenzyme wiht IC50 values 3.78 micrograms/mL.Note : - Their Lineweaver-Burk plots and Dixon plots showed that NF, N-NF, and HMA competitively inhibited CYP2D6 activity with Ki values of 1.88, 2.34 and 1.56 micromolars, respectively - Conclusion, lotus leaves exert a potent inhibitory effect on CYP2D6 isoenzyme. - Abbreviation LAE lotus leaf alcoholic extract AF the alkaloid fraction FF the flavonoid fraction NF nuciferine N-NF N-nornuciferine HMA 2-hydroxy-1-methoxyaporphine
Part Used : ใบActivity : CYP2D6 INHIBITIONSolvent/Active Compound : N-nornuciferine (N-NF)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.5-100 micromolarsDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The inhibitory effects of N-NF on CYP2D6 isoenzyme wiht IC50 values 3.76 micrograms/mL.Note : - Their Lineweaver-Burk plots and Dixon plots showed that NF, N-NF, and HMA competitively inhibited CYP2D6 activity with Ki values of 1.88, 2.34 and 1.56 micromolars, respectively - Conclusion, lotus leaves exert a potent inhibitory effect on CYP2D6 isoenzyme. - Abbreviation LAE lotus leaf alcoholic extract AF the alkaloid fraction FF the flavonoid fraction NF nuciferine N-NF N-nornuciferine HMA 2-hydroxy-1-methoxyaporphine
Part Used : ใบActivity : CYP2D6 INHIBITIONSolvent/Active Compound : 2-hydroxy-1-methoxyaporphine (HMA)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.5-100 micromolarsDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The inhibitory effects of HMA on CYP2D6 isoenzyme wiht IC50 values 3.15 micrograms/mL.Note : - Their Lineweaver-Burk plots and Dixon plots showed that NF, N-NF, and HMA competitively inhibited CYP2D6 activity with Ki values of 1.88, 2.34 and 1.56 micromolars, respectively - Conclusion, lotus leaves exert a potent inhibitory effect on CYP2D6 isoenzyme. - Abbreviation LAE lotus leaf alcoholic extract AF the alkaloid fraction FF the flavonoid fraction NF nuciferine N-NF N-nornuciferine HMA 2-hydroxy-1-methoxyaporphine
Part Used : เมล็ดActivity : CYP2D6 INHIBITIONSolvent/Active Compound : neferineType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Dextromethorphan*/Dextromethorfan/DextromorphanDose/Conc.(drug) : -Result : PositiveRemark : Result: Neferine did not display any remarkable time-dependent or NADPH-dependent inhibition of CYP2D6. These findings may be partially due to the substrate selected for CYP2D6, dextromethorphan. Consequently, from this study, it can be assumed that Neferine displays a weak or negligible inhibition of CYP1A2 and CYP2D6 in vitro.Note : Phenacetin, dextromethorphan and testosterone, respectively, were used as CYP1A2, CYP2D6 and CYP3A4 substrates, and their metabolites were determined by validated HPLC methodologies.
