| Synonym |
| Thai / English name |
Part Used : เมล็ดActivity : CYP1A2 INHIBITIONSolvent/Active Compound : NeferineType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 5 microlitersDuration : 25 minutesType of interaction : PharmacokineticsInteraction with drug : Phenacetin*/AcetophenetidinDose/Conc.(drug) : -Result : PositiveRemark : The IC50 values of neferine on CYP1A2 was>320 micromolar (>200 micrograms/mL).
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : NeferineType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 5 microlitersDuration : 25 minutesType of interaction : PharmacokineticsInteraction with drug : Phenacetin*/AcetophenetidinDose/Conc.(drug) : -Result : PositiveRemark : The IC50 values of neferine on CYP1A2 was>320 micromolar (>200 micrograms/mL).
Part Used : เมล็ดActivity : CYP1A2 INHIBITIONSolvent/Active Compound : neferineType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Phenacetin*/AcetophenetidinDose/Conc.(drug) : -Result : EquivocalRemark : Result: Neferine showed a nonmechanistic inhibition of CYP1A2. Neferine inhibits CYP1A2 activity only to a minor extent, and in this study, demonstrates a non-time-dependent increase in the inhibition of CYP1A2, meaning that Nef did not fulfil the criteria as a mechanism-based inhibitor of CYP1A2. Consequently, from this study, it can be assumed the Neferine displays a weak or negligible inhibiton of CYP1A2 and CYP2D6 in vitro.Note : Phenacetin, dextromethorphan and testosterone, respectively, were used as CYP1A2, CYP2D6 and CYP3A4 substrates, and their metabolites were determined by validated HPLC methodologies.
