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Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : NeferineType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 5 microlitersDuration : 25 minutesType of interaction : PharmacokineticsInteraction with drug : Dextromethorphan*/Dextromethorfan/DextromorphanDose/Conc.(drug) : -Result : PositiveRemark : The IC50 values of neferine on CYP2D6 was 73.4+/-16.8 micromolar (45.8+/-10.5 micrograms/mL).
Part Used : เมล็ดActivity : CYP2D6 INHIBITIONSolvent/Active Compound : NeferineType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 5 microlitersDuration : 25 minutesType of interaction : PharmacokineticsInteraction with drug : Dextromethorphan*/Dextromethorfan/DextromorphanDose/Conc.(drug) : -Result : PositiveRemark : The IC50 values of neferine on CYP2D6 was 73.4+/-16.8 micromolar (45.8+/-10.5 micrograms/mL).
Part Used : เมล็ดActivity : CYP2D6 INHIBITIONSolvent/Active Compound : neferineType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Dextromethorphan*/Dextromethorfan/DextromorphanDose/Conc.(drug) : -Result : PositiveRemark : Result: Neferine did not display any remarkable time-dependent or NADPH-dependent inhibition of CYP2D6. These findings may be partially due to the substrate selected for CYP2D6, dextromethorphan. Consequently, from this study, it can be assumed that Neferine displays a weak or negligible inhibition of CYP1A2 and CYP2D6 in vitro.Note : Phenacetin, dextromethorphan and testosterone, respectively, were used as CYP1A2, CYP2D6 and CYP3A4 substrates, and their metabolites were determined by validated HPLC methodologies.
