ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

UMBELLIFERAE (APIACEAE) Centella asiatica (L.) Urb.

Synonym

none ...

Thai / English name

บัวบก*

[1-1] of 8 article(s) found

หน้า 1 2 3 4

[1] IN VITRO MODULATORY EFFECTS ON THREE MAJOR HUMAN CYTOCHROME P450 ENZYMES BY MULTIPLE ACTIVE CONSTITUENTS AND EXTRACTS OF CENTELLA ASIATICA.
PAN Y,ABD-RASHID BA,ISMAIL Z,ET AL.
J ETHNOPHARMACOL 2010 Vol.130(),275-83 $31097 [Full]

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : aqueous

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : - IC50 = 599.0 microgram/ml

Note : - CYP2C9 was more susceptible to inhibitory effects by C. asiatica extracts compared to CYP2D6 and CYP3A4.

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : aqueous

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : - IC50 = 413.1 microgram/ml

Note : - CYP2C9 was more susceptible to inhibitory effects by C. asiatica extracts compared to CYP2D6 and CYP3A4.

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : aqueous

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : - IC50 = 229.5 microgram/ml

Note : - CYP2C9 was more susceptible to inhibitory effects by C. asiatica extracts compared to CYP2D6 and CYP3A4.

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : ethanol

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : - IC50 = 28.3 microgram/ml - Moderate drgree of CYP2C9 inhibition was observed in ethanol extract (Ki = 39.1 microgram/ml)

Note : - CYP2C9 was more susceptible to inhibitory effects by C. asiatica extracts compared to CYP2D6 and CYP3A4.

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : ethanol

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : - IC50 = 418.9 microgram/ml

Note : - CYP2C9 was more susceptible to inhibitory effects by C. asiatica extracts compared to CYP2D6 and CYP3A4.

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : ethanol

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : - IC50 = 465.8 microgram/ml

Note : - CYP2C9 was more susceptible to inhibitory effects by C. asiatica extracts compared to CYP2D6 and CYP3A4.

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : dichloromethane extract

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : - IC50 = 17.2 microgram/ml - Moderate degree of CYP2C9 inhibition was observed in dichloromethane extract (Ki = 26.6 microgram/ml).

Note : - CYP2C9 was more susceptible to inhibitory effects by C. asiatica extracts compared to CYP2D6 and CYP3A4.

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : dichloromethane

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : - IC50 = 123.3 microgram/ml

Note : - CYP2C9 was more susceptible to inhibitory effects by C. asiatica extracts compared to CYP2D6 and CYP3A4.

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : dichloromethane extract

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : - IC50 = 138.4 microgram/ml

Note : - CYP2C9 was more susceptible to inhibitory effects by C. asiatica extracts compared to CYP2D6 and CYP3A4.

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : hexane

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : - IC50 = 117.9 microgram/ml

Note : - CYP2C9 was more susceptible to inhibitory effects by C. asiatica extracts compared to CYP2D6 and CYP3A4.

หน้า 1 2 3 4

EN

Web Link ที่เกี่ยวข้อง

ที่อยู่