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Part Used : ไม่ระบุActivity : CYP2E1 INHIBITIONSolvent/Active Compound : The standard extract of Centella asiatica (ECa233); triterpenoid glycosides not less than 80% which consisted of 43% of madecassoside and 39% of asiaticosideType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : ECa233 at 10, 100 and 1,000 mg/kg/dayDuration : 90 consecutive daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Result: ECa233 did not affect total CYP content as well as the activities of CYP1A1,CYP1A2, CYP2B1/2B2, CYP2E1 and CYP3A in both male and female rats.
Part Used : ไม่ระบุActivity : CYP2E1 INHIBITIONSolvent/Active Compound : The standard extract of Centella asiatica (ECa233); triterpenoid glycosides not less than 80% which consisted of 43% of madecassoside and 39% of asiaticosideType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : ECa233 at 0, 100, 250, 500, 1,000 and 2,000 micrograms/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Result: ECa233 had no inhibitory effect on the activities of CYP1A1, CYP2E1 and CYP3A at concentrations up to 2,000 mg/ml.
