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Part Used : ไม่ระบุActivity : CYP2D6 INHIBITIONSolvent/Active Compound : aqueousType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : - IC50 = 413.1 microgram/mlNote : - CYP2C9 was more susceptible to inhibitory effects by C. asiatica extracts compared to CYP2D6 and CYP3A4.
Part Used : ไม่ระบุActivity : CYP2D6 INHIBITIONSolvent/Active Compound : ethanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : - IC50 = 418.9 microgram/mlNote : - CYP2C9 was more susceptible to inhibitory effects by C. asiatica extracts compared to CYP2D6 and CYP3A4.
Part Used : ไม่ระบุActivity : CYP2D6 INHIBITIONSolvent/Active Compound : dichloromethaneType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : - IC50 = 123.3 microgram/mlNote : - CYP2C9 was more susceptible to inhibitory effects by C. asiatica extracts compared to CYP2D6 and CYP3A4.
Part Used : ไม่ระบุActivity : CYP2D6 INHIBITIONSolvent/Active Compound : hexaneType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : - IC50 = 294.1 microgram/mlNote : - CYP2C9 was more susceptible to inhibitory effects by C. asiatica extracts compared to CYP2D6 and CYP3A4.
Part Used : ไม่ระบุActivity : CYP2D6 INHIBITIONSolvent/Active Compound : asiatic acidType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : - IC50 = 67.9 microgram/ml (138.9 micromolar)Note : - CYP2C9 was more susceptible to inhibitory effects by C. asiatica extracts compared to CYP2D6 and CYP3A4.
Part Used : ไม่ระบุActivity : CYP2D6 INHIBITIONSolvent/Active Compound : asiaticosideType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : - IC50 = > 1,500 microgram/ml (> 1,563.9 micromolar)Note : - CYP2C9 was more susceptible to inhibitory effects by C. asiatica extracts compared to CYP2D6 and CYP3A4.
Part Used : ไม่ระบุActivity : CYP2D6 INHIBITIONSolvent/Active Compound : madecassic acidType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : - IC50 = 30.7 microgram/ml (60.8 micromolar)Note : - CYP2C9 was more susceptible to inhibitory effects by C. asiatica extracts compared to CYP2D6 and CYP3A4.
Part Used : ไม่ระบุActivity : CYP2D6 INHIBITIONSolvent/Active Compound : asiaticoside, asiatic acid and madecassic acidType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Centella asiatica (CA) extracts and active constituents inhibited CYP2C9, CYP2D6 and CYP3A4 activities with varying potency with CYP2C9 being the most susceptible isoform to inhibition. Significant inhibition was observed for asiatic acid and CA ethanol and dichloromethane extracts, implying involvement of semipolar constituents from CA in the effect. This study suggested that CA could cause drug-herb interactions through CYP2C9 inhibitiont.
Part Used : ใบActivity : CYP2D6 INHIBITIONSolvent/Active Compound : ethanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The ethanolic extract of Centella asiatica (white stem cultivars) inhibited CYP2D6 activity with IC50 value 213.3+/-205.0 microgram/ml.Note : Testosterone 6beta-hydroxylase and dextromethorphan O-demethylase were used as maker of CYP3A4 and CYP2D6 activity, respectively.
Part Used : ใบActivity : CYP2D6 INHIBITIONSolvent/Active Compound : ethanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The ethanolic extract of Centella asiatica (red stem cultivars) inhibited CYP2D6 activity with IC50 value 83.3+/-20.8 microgram/ml.Note : Testosterone 6beta-hydroxylase and dextromethorphan O-demethylase were used as maker of CYP3A4 and CYP2D6 activity, respectively.
