ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

UMBELLIFERAE (APIACEAE) Centella asiatica (L.) Urb.

Synonym

none ...

Thai / English name

บัวบก*

[1-2] of 2 article(s) found

หน้า 1

[1] IN VITRO MODULATORY EFFECTS ON THREE MAJOR HUMAN CYTOCHROME P450 ENZYMES BY MULTIPLE ACTIVE CONSTITUENTS AND EXTRACTS OF CENTELLA ASIATICA.
PAN Y,ABD-RASHID BA,ISMAIL Z,ET AL.
J ETHNOPHARMACOL 2010 Vol.130(),275-83 $31097 [Full]

Part Used : ไม่ระบุ
Activity : CYP2C9 INHIBITION

Solvent/Active Compound : aqueous

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : - IC50 = 599.0 microgram/ml

Note : - CYP2C9 was more susceptible to inhibitory effects by C. asiatica extracts compared to CYP2D6 and CYP3A4.

Part Used : ไม่ระบุ
Activity : CYP2C9 INHIBITION

Solvent/Active Compound : ethanol

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : - IC50 = 28.3 microgram/ml - Moderate drgree of CYP2C9 inhibition was observed in ethanol extract (Ki = 39.1 microgram/ml)

Note : - CYP2C9 was more susceptible to inhibitory effects by C. asiatica extracts compared to CYP2D6 and CYP3A4.

Part Used : ไม่ระบุ
Activity : CYP2C9 INHIBITION

Solvent/Active Compound : dichloromethane extract

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : - IC50 = 17.2 microgram/ml - Moderate degree of CYP2C9 inhibition was observed in dichloromethane extract (Ki = 26.6 microgram/ml).

Note : - CYP2C9 was more susceptible to inhibitory effects by C. asiatica extracts compared to CYP2D6 and CYP3A4.

Part Used : ไม่ระบุ
Activity : CYP2C9 INHIBITION

Solvent/Active Compound : hexane

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : - IC50 = 117.9 microgram/ml

Note : - CYP2C9 was more susceptible to inhibitory effects by C. asiatica extracts compared to CYP2D6 and CYP3A4.

Part Used : ไม่ระบุ
Activity : CYP2C9 INHIBITION

Solvent/Active Compound : asiatic acid

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : - IC50 = 33.1 microgram/ml (67.7 micromolar) - Of particular interest is the potent inhibitory effect of asiatic acid on CYP2C9 (Ki = 9.1 microgram/ml)

Note : - CYP2C9 was more susceptible to inhibitory effects by C. asiatica extracts compared to CYP2D6 and CYP3A4.

Part Used : ไม่ระบุ
Activity : CYP2C9 INHIBITION

Solvent/Active Compound : asiaticoside

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : - IC50 = 1,070.2 microgram/ml (1,115.8 micromolar)

Note : - CYP2C9 was more susceptible to inhibitory effects by C. asiatica extracts compared to CYP2D6 and CYP3A4.

Part Used : ไม่ระบุ
Activity : CYP2C9 INHIBITION

Solvent/Active Compound : madecassic acid

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : - IC50 = 40.8 microgram/ml (80.8 micromolar)

Note : - CYP2C9 was more susceptible to inhibitory effects by C. asiatica extracts compared to CYP2D6 and CYP3A4.

[2] IN VITRO MODULATORY EFFECTS ON THREE MAJOR HUMAN CYTOCHROME P450 ENZYMES BY MULTIPLE ACTIVE CONSTITUENTS AND EXTRACTS OF CENTELLA ASIATICA.
YAN PAN,BADRUL AMINI ABD-RASHID,ZAKIAH ISMAIL,ET AL.
J ETHNOPHARMACOL 2010 Vol.130(),275-83 $41705 [Full]

Part Used : ไม่ระบุ
Activity : CYP2C9 INHIBITION

Solvent/Active Compound : asiaticoside, asiatic acid and madecassic acid

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Centella asiatica (CA) extracts and active constituents inhibited CYP2C9, CYP2D6 and CYP3A4 activities with varying potency with CYP2C9 being the most susceptible isoform to inhibition. Significant inhibition was observed for asiatic acid and CA ethanol and dichloromethane extracts, implying involvement of semipolar constituents from CA in the effect. This study suggested that CA could cause drug-herb interactions through CYP2C9 inhibitiont.

หน้า 1

EN

Web Link ที่เกี่ยวข้อง

ที่อยู่