| Synonym |
| Thai / English name |
Part Used : -Activity : CYTOCHROME P-450 INHIBITIONSolvent/Active Compound : dichloromethane extract, ethanol extractType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark :Note : Andrographis paniculata (AP) ethanol extract and Centella asiatica (CA) dichloromethane extract exhibited mixed type inhibition towards CYP2C19 with Ki values of 67.1 and 16.4 microgram/ml respectively; CA ethanol extract and Orthosiphon stamineus (OS) petroleum ether extract competitively CYP2C19 activity (Ki =39.6 and 41.5 microgram/ml respectively). Eupatorin (a major active constituent of OS) was found to significantly inhibit CYP2C19 by mixed type inhibition (Ki=7.1 microgram/ml or 20.6 micromolar
Part Used : ไม่ระบุActivity : CYTOCHROME P-450 INHIBITIONSolvent/Active Compound : asiaticoside, asiatic acid and madecassic acidType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Centella asiatica (CA) extracts and active constituents inhibited CYP2C9, CYP2D6 and CYP3A4 activities with varying potency with CYP2C9 being the most susceptible isoform to inhibition. Significant inhibition was observed for asiatic acid and CA ethanol and dichloromethane extracts, implying involvement of semipolar constituents from CA in the effect. This study suggested that CA could cause drug-herb interactions through CYP2C9 inhibitiont.
Part Used : ไม่ระบุActivity : CYTOCHROME P-450 INHIBITIONSolvent/Active Compound : The standard extract of Centella asiatica (ECa233); triterpenoid glycosides not less than 80% which consisted of 43% of madecassoside and 39% of asiaticosideType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : ECa233 at 10, 100 and 1,000 mg/kg/dayDuration : 90 consecutive daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Result: ECa233 did not affect total CYP content as well as the activities of CYP1A1,CYP1A2, CYP2B1/2B2, CYP2E1 and CYP3A in both male and female rats.
