ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ใบ

Activity : DRUG INTERACTION

Solvent/Active Compound : -

Type of experiment : in vivo

Type of animal : rat

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : Oral administration

Dose/Conc.(herb) : 500 mg/kg

Duration : The anticonvulsant activity was assessed by the classical Maximal Electro Shock (MES) test at 1, 3, 6 and 24 h after drug administration.

Type of interaction : Pharmacodynamics

Interaction with drug : Carbamazepine*/CBZ

Dose/Conc.(drug) : -

Result : Positive

Remark : Results: When Centella asiatica (CA) was combined with phenytoin, though seizure protection was seen, this effect was not statistically significant. When CA was combined with phenobarbitone, the protective activity of phenobarbitone declined from 50% to 0% (p < 0.05) at 3 h. When CA was combined with carbamazepine, significant seizure protection was seen only at 1 and 3 h (p < 0.05).

Note : Data incomplete.

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