ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ไม่ระบุ

Activity : PROTEIN EXPRESSION INHIBITION

Solvent/Active Compound : Thymoquinone

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : 50 micromolars

Duration : -

Type of interaction : Pharmacodynamics

Interaction with drug : 5-fluorouracil (5-FU)*/Fluorouracil/FU

Dose/Conc.(drug) : 75 micrograms/mL

Result : Positive

Remark : Type of experiment: gastric cancer cell lines Results: Pretreatment with Thymoquinone (TQ) significantly increased the apoptotic effects induced by 5-fluorouracil (5-FU) in gastric cancer cell lines in vitro. TQ enhanced the 5-FU-induced killing of gastric cancer cells by mediating the downregulation of the anti-apoptotic protein bcl-2, the upregulation of the pro-apoptotic protein bax, and the activation of both caspase-3 and caspase-9.

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