| Synonym |
| Thai / English name |
Part Used : ไม่ระบุActivity : APOPTOSIS INDUCTIONSolvent/Active Compound : ThymoquinoneType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 50 micromolarsDuration : -Type of interaction : PharmacodynamicsInteraction with drug : 5-fluorouracil (5-FU)*/Fluorouracil/FUDose/Conc.(drug) : 75 micrograms/mLResult : PositiveRemark : Type of experiment: gastric cancer cell lines Results: Pretreatment with Thymoquinone (TQ) significantly increased the apoptotic effects induced by 5-fluorouracil (5-FU) in gastric cancer cell lines in vitro. TQ enhanced the 5-FU-induced killing of gastric cancer cells by mediating the downregulation of the anti-apoptotic protein bcl-2, the upregulation of the pro-apoptotic protein bax, and the activation of both caspase-3 and caspase-9.
Part Used : น้ำมันหอมระเหยActivity : APOPTOSIS INDUCTIONSolvent/Active Compound : thymoquinoneType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : -Remark : type of experiment: Doxorubicin, thymoquinone and equimolar mixtures of both were tested for cytotoxicity on human cells of HL-60 leukaemia, 518A2 melanoma, HT-29 colon, KB-V1 cervix, and MCF-7 breast carcinomas as well as multi-drug-resistant variants thereof and on non-malignant human fibroblasts (HF). Results: Thymoquinone improved the anti-cancer properties of doxorubicin in a cell line-specific manner. We found a significant rise of the growth inhibition by doxorubicin in HL-60 and multi-drug-resistant MCF-7/TOPO cells when thymoquinone had been added.
