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Part Used : น้ำมันจากเมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : Nigella sativa (NS) oilType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 1.2 g/kg amikacin (AMK) was injected i.p., to rats as a single dose. Two dose of NS oil (0.5 mL) were given orally at the day of injection and one day before injection of AMK. The rats were sacrificed on the eighth days.Duration : 8 daysType of interaction : PharmacodynamicsInteraction with drug : AmikacinDose/Conc.(drug) : -Result : PositiveRemark : Result: NS oil significantly decreased the levels of nitric oxide, malondialdehyde and total antioxidant capacity. Furthermore, it increased the level of reduced glutathione. These changes are indicative for lower tissue damage and reduced free radical formation. These results were coinciding with the lower levels of urea, uric acid and creatinine (which were significantly elevated in amikacin treated groups). Semi-quantitative analysis of cellular infiltration, necrosis of tubular cells and tubular cellular damage indicated the protective effect of NS oil in reducing renal damage induced by amikacin.Note : By using a rat model, Nigella sativa oil and Allium sativum extract efficiently ameliorated the renal toxic effect of amikacin.
Part Used : น้ำมันจากเมล็ดActivity : ANTINEPHROTOXICSolvent/Active Compound : Nigella sativa (NS) oilType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 1.2 g/kg amikacin (AMK) was injected i.p., to rats as a single dose. Two dose of NS oil (0.5 mL) were given orally at the day of injection and one day before injection of AMK. The rats were sacrificed on the eighth days.Duration : 8 daysType of interaction : PharmacodynamicsInteraction with drug : AmikacinDose/Conc.(drug) : -Result : PositiveRemark : Result: NS oil significantly decreased the levels of nitric oxide, malondialdehyde and total antioxidant capacity. Furthermore, it increased the level of reduced glutathione. These changes are indicative for lower tissue damage and reduced free radical formation. These results were coinciding with the lower levels of urea, uric acid and creatinine (which were significantly elevated in amikacin treated groups). Semi-quantitative analysis of cellular infiltration, necrosis of tubular cells and tubular cellular damage indicated the protective effect of NS oil in reducing renal damage induced by amikacin.Note : By using a rat model, Nigella sativa oil and Allium sativum extract efficiently ameliorated the renal toxic effect of amikacin.
