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Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : Methanol and hexane extracts of NigellaType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Amoxicillin*/AmoxycillinDose/Conc.(drug) : -Result : PositiveRemark : Result: The effect of Nigella sativa on bioavailability of amoxicillin was investigated in everted rat intestinal sacs. The in vitro studies both with methanol and hexane extracts of Nigella increased the permeation of amoxicillin significantly (P<0.001) as compared to control. Permeation was also found to be significantly higher for the hexane extract (P<0.001) in comparison to methanol extract at the same dose levels. Nigella enhanced amoxicillin availability in both in vivo and in vitro studies.Note : Data from review
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Methanol and hexane extracts of NigellaType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Amoxicillin*/AmoxycillinDose/Conc.(drug) : -Result : PositiveRemark : Result: The effect of Nigella sativa on bioavailability of amoxicillin was investigated in everted rat intestinal sacs. The in vitro studies both with methanol and hexane extracts of Nigella increased the permeation of amoxicillin significantly (P<0.001) as compared to control. Permeation was also found to be significantly higher for the hexane extract (P<0.001) in comparison to methanol extract at the same dose levels. Nigella enhanced amoxicillin availability in both in vivo and in vitro studies.Note : Data from review
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Hexane extracts of NigellaType of experiment : in vitroType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Amoxicillin*/AmoxycillinDose/Conc.(drug) : -Result : PositiveRemark : Result: In vivo experiments revealed that Cmax of amoxicillin in rat plasma when administered orally alone and in combination with hexane extract increased correspondingly from 4, 138.251+/-156.930 to 5,995.045+/-196.280 ng/mL while as AUC 0-> t increased from 8,890.40+/-143.33 to 13,483.46+/-152.45 ng/mL/h. Nigella enhanced amoxicillin availability in both in vivo and in vitro studies.Note : Data from review
Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : Hexane extracts of NigellaType of experiment : in vitroType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Amoxicillin*/AmoxycillinDose/Conc.(drug) : -Result : PositiveRemark : Result: In vivo experiments revealed that Cmax of amoxicillin in rat plasma when administered orally alone and in combination with hexane extract increased correspondingly from 4, 138.251+/-156.930 to 5,995.045+/-196.280 ng/mL while as AUC 0-> t increased from 8,890.40+/-143.33 to 13,483.46+/-152.45 ng/mL/h. Nigella enhanced amoxicillin availability in both in vivo and in vitro studies.Note : Data from review
