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Thai / English name |
Part Used : ไม่ระบุActivity : APOPTOSIS INDUCTIONSolvent/Active Compound : ThymoquinoneType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 50 micromolarsDuration : -Type of interaction : PharmacodynamicsInteraction with drug : 5-fluorouracil (5-FU)*/Fluorouracil/FUDose/Conc.(drug) : 75 micrograms/mLResult : PositiveRemark : Type of experiment: gastric cancer cell lines Results: Pretreatment with Thymoquinone (TQ) significantly increased the apoptotic effects induced by 5-fluorouracil (5-FU) in gastric cancer cell lines in vitro. TQ enhanced the 5-FU-induced killing of gastric cancer cells by mediating the downregulation of the anti-apoptotic protein bcl-2, the upregulation of the pro-apoptotic protein bax, and the activation of both caspase-3 and caspase-9.
Part Used : ไม่ระบุActivity : PROTEIN EXPRESSION STIMULATIONSolvent/Active Compound : ThymoquinoneType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 50 micromolarsDuration : -Type of interaction : PharmacodynamicsInteraction with drug : 5-fluorouracil (5-FU)*/Fluorouracil/FUDose/Conc.(drug) : 75 micrograms/mLResult : PositiveRemark : Type of experiment: gastric cancer cell lines Results: Pretreatment with Thymoquinone (TQ) significantly increased the apoptotic effects induced by 5-fluorouracil (5-FU) in gastric cancer cell lines in vitro. TQ enhanced the 5-FU-induced killing of gastric cancer cells by mediating the downregulation of the anti-apoptotic protein bcl-2, the upregulation of the pro-apoptotic protein bax, and the activation of both caspase-3 and caspase-9.
Part Used : ไม่ระบุActivity : CASPASE-3 STIMULATIONSolvent/Active Compound : ThymoquinoneType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 50 micromolarsDuration : -Type of interaction : PharmacodynamicsInteraction with drug : 5-fluorouracil (5-FU)*/Fluorouracil/FUDose/Conc.(drug) : 75 micrograms/mLResult : PositiveRemark : Type of experiment: gastric cancer cell lines Results: Pretreatment with Thymoquinone (TQ) significantly increased the apoptotic effects induced by 5-fluorouracil (5-FU) in gastric cancer cell lines in vitro. TQ enhanced the 5-FU-induced killing of gastric cancer cells by mediating the downregulation of the anti-apoptotic protein bcl-2, the upregulation of the pro-apoptotic protein bax, and the activation of both caspase-3 and caspase-9.
Part Used : ไม่ระบุActivity : PROTEIN EXPRESSION INHIBITIONSolvent/Active Compound : ThymoquinoneType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 50 micromolarsDuration : -Type of interaction : PharmacodynamicsInteraction with drug : 5-fluorouracil (5-FU)*/Fluorouracil/FUDose/Conc.(drug) : 75 micrograms/mLResult : PositiveRemark : Type of experiment: gastric cancer cell lines Results: Pretreatment with Thymoquinone (TQ) significantly increased the apoptotic effects induced by 5-fluorouracil (5-FU) in gastric cancer cell lines in vitro. TQ enhanced the 5-FU-induced killing of gastric cancer cells by mediating the downregulation of the anti-apoptotic protein bcl-2, the upregulation of the pro-apoptotic protein bax, and the activation of both caspase-3 and caspase-9.
Part Used : ไม่ระบุActivity : CASPASE STIMULATIONSolvent/Active Compound : ThymoquinoneType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 50 micromolarsDuration : -Type of interaction : PharmacodynamicsInteraction with drug : 5-fluorouracil (5-FU)*/Fluorouracil/FUDose/Conc.(drug) : 75 micrograms/mLResult : PositiveRemark : Type of experiment: gastric cancer cell lines Results: Pretreatment with Thymoquinone (TQ) significantly increased the apoptotic effects induced by 5-fluorouracil (5-FU) in gastric cancer cell lines in vitro. TQ enhanced the 5-FU-induced killing of gastric cancer cells by mediating the downregulation of the anti-apoptotic protein bcl-2, the upregulation of the pro-apoptotic protein bax, and the activation of both caspase-3 and caspase-9.
Part Used : ไม่ระบุActivity : CARCINOGENESIS INHIBITIONSolvent/Active Compound : ThymoquinoneType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 50 micromolarsDuration : -Type of interaction : PharmacodynamicsInteraction with drug : 5-fluorouracil (5-FU)*/Fluorouracil/FUDose/Conc.(drug) : 75 micrograms/mLResult : PositiveRemark : Type of experiment: gastric cancer cell lines Results: Pretreatment with Thymoquinone (TQ) significantly increased the apoptotic effects induced by 5-fluorouracil (5-FU) in gastric cancer cell lines in vitro. TQ enhanced the 5-FU-induced killing of gastric cancer cells by mediating the downregulation of the anti-apoptotic protein bcl-2, the upregulation of the pro-apoptotic protein bax, and the activation of both caspase-3 and caspase-9.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : ThymoquinoneType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 50 micromolarsDuration : -Type of interaction : PharmacodynamicsInteraction with drug : 5-fluorouracil (5-FU)*/Fluorouracil/FUDose/Conc.(drug) : 75 micrograms/mLResult : PositiveRemark : Type of experiment: gastric cancer cell lines Results: Pretreatment with Thymoquinone (TQ) significantly increased the apoptotic effects induced by 5-fluorouracil (5-FU) in gastric cancer cell lines in vitro. TQ enhanced the 5-FU-induced killing of gastric cancer cells by mediating the downregulation of the anti-apoptotic protein bcl-2, the upregulation of the pro-apoptotic protein bax, and the activation of both caspase-3 and caspase-9.
Part Used : ไม่ระบุActivity : CELL GROWTH INHIBITION EFFECTSolvent/Active Compound : ThymoquinoneType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 50 micromolarsDuration : -Type of interaction : PharmacodynamicsInteraction with drug : 5-fluorouracil (5-FU)*/Fluorouracil/FUDose/Conc.(drug) : 75 micrograms/mLResult : PositiveRemark : Type of experiment: gastric cancer cell lines Results: Pretreatment with Thymoquinone (TQ) significantly increased the apoptotic effects induced by 5-fluorouracil (5-FU) in gastric cancer cell lines in vitro. TQ enhanced the 5-FU-induced killing of gastric cancer cells by mediating the downregulation of the anti-apoptotic protein bcl-2, the upregulation of the pro-apoptotic protein bax, and the activation of both caspase-3 and caspase-9.
Part Used : ไม่ระบุActivity : PROTEIN DOWNREGULATION ACTIVITYSolvent/Active Compound : ThymoquinoneType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 50 micromolarsDuration : -Type of interaction : PharmacodynamicsInteraction with drug : 5-fluorouracil (5-FU)*/Fluorouracil/FUDose/Conc.(drug) : 75 micrograms/mLResult : PositiveRemark : Type of experiment: gastric cancer cell lines Results: Pretreatment with Thymoquinone (TQ) significantly increased the apoptotic effects induced by 5-fluorouracil (5-FU) in gastric cancer cell lines in vitro. TQ enhanced the 5-FU-induced killing of gastric cancer cells by mediating the downregulation of the anti-apoptotic protein bcl-2, the upregulation of the pro-apoptotic protein bax, and the activation of both caspase-3 and caspase-9.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : ThymoquinoneType of experiment : in vitroType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 20 mg/kgDuration : 30 daysType of interaction : PharmacodynamicsInteraction with drug : 5-fluorouracil (5-FU)*/Fluorouracil/FUDose/Conc.(drug) : 19 mg/kgResult : PositiveRemark : Type of experiment: xenograft tumor mouse model Results: TQ and 5-FU treatment led to a significant decrease in tumor weight and size compared with the control group.