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Part Used : น้ำมันจากเมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : Thymoquinone (TQ)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : TQ 50 mg/L in drinking water for 5 days before a single dose of cyclophosphamide (CP) (200 mg/kg, IP)Duration : 5 days, Seven days after the administration of CP, all rats were anesthetized with ether and blood samples were obtained by heart puncture.Type of interaction : PharmacodynamicsInteraction with drug : Cyclophosphamide*/CPM/CTX/CYTDose/Conc.(drug) : -Result : PositiveRemark : Result: CP reslted in a significant increase in serum creatine kinase, lactate dehydrogenase, cholesterol, triglycerides, creatinine, urea, and tumor necrosis factor-alpha. In heart tissues, CP resulted in a significant increase in thiobarbituric acid reactive substances and total nitrate/nitrite and a significant decrease in reduced glutathione, glutathione peroxidase, catalase, and adenosine triphosphate levels. Interestingly, TQ supplementation resulted in a complete reversal of all the biochemical changes induced by CP to their control values.
Part Used : น้ำมันจากเมล็ดActivity : ANTICARDIOTOXIC EFFECTSolvent/Active Compound : Thymoquinone (TQ)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : TQ 50 mg/L in drinking water for 5 days before a single dose of cyclophosphamide (CP) (200 mg/kg, IP)Duration : 5 days, Seven days after the administration of CP, all rats were anesthetized with ether and blood samples were obtained by heart puncture.Type of interaction : PharmacodynamicsInteraction with drug : Cyclophosphamide*/CPM/CTX/CYTDose/Conc.(drug) : -Result : PositiveRemark : Result: CP reslted in a significant increase in serum creatine kinase, lactate dehydrogenase, cholesterol, triglycerides, creatinine, urea, and tumor necrosis factor-alpha. In heart tissues, CP resulted in a significant increase in thiobarbituric acid reactive substances and total nitrate/nitrite and a significant decrease in reduced glutathione, glutathione peroxidase, catalase, and adenosine triphosphate levels. Interestingly, TQ supplementation resulted in a complete reversal of all the biochemical changes induced by CP to their control values.
