Part Used : เมล็ด
Activity : DRUG INTERACTION
Solvent/Active Compound : -
Type of experiment : human
Type of animal : -
Type of study : Open trial
N(Total) : -
N(Treatment) : -
Sex : Both sex
Age : 2-18 yrs
Route : Oral administration
Dose/Conc.(herb) : 40 mg/kg in 2 equally divided doses
Duration : 6 months
Type of interaction : Pharmacokinetics
Interaction with drug : Prednisolone*/Deltahydrocortisone/Metacortandralone
Dose/Conc.(drug) : daunorubicin (1.5 mg/kg, i/v weekly), vincristine (4 mg/kg i/v twice weekly) and prednisolone (5 mg/kg per day orally in 3 divided doses)
Remark : Group III tretment with conventional drugs + Nigella sativa seeds proved best among the three treatments. It is conceivable, therefore, that Nigella sativa seeds could help in treating acute lymphoblastic leukemia in children when given incombination with other cytotoxic drugs.
Note : Acute lymphoblastic leukemia (ALL), the selected 48 (16 in each, subjects completed the study were randomly divided into 3 groups. In conventional therapy: group I, daunorubicin (1.5 mg/kg, iv weekly), group II vincristine (4 mg/kg, iv twice weekly) and prednisolone (5 mg/kg/day orally in 3 divided doses) were prescribed to patients of ALL as induction therapy of 3 months. Powdered Nigella sativa seed were given to Group III patients of ALL without L-asparaginase.
