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Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Chloroquine*/Chloroquine sulphateDose/Conc.(drug) : 10 mg/kg body weight.Result : PositiveRemark : Percentage suppression on day 4 was highest for NSSF with 86.1%, followed by NSSF + CQ with 86% which were very significant (P < 0.001), compared to CQ (36.1%). Results show that up till day 8 post infection, treatment with NSSF and NSSF + CQ had better suppressive effects on parasitaemia than CQ. There was 100% survival amongst P. berghei infected mice treated with NSSF, NSOF and combination with CQ, until the experiments were terminated 45 days later, while treatment with CQ had 60% survival rate.Note : The study was conducted in two phases. In the first phase, animals were selected randomly and placed in 4 groups; group 1 Nigella sativa seed plus feed (NSSF), group 2 NSSF + chloroquine (CQ), group 3 Nigella sativa oil extract in feed (NSOF) and group 4 NSOF + CQ. In the phase 2 experiments, mice were placed in 4 groups; groups 1 and 2 were given 5 mg/kg, 10 mg/kg doses of Nigella sativa oil extracts while groups 3 and 4 were given a combination of 5 mg/kg + CQ and 10 mg/kg + CQ respectively.
Part Used : น้ำมันActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Chloroquine*/Chloroquine sulphateDose/Conc.(drug) : 10 mg/kg body weight.Result : PositiveRemark : In NSOF + CQ, % suppression was higher than with chloroquine alone with a 99.9% at 4 days post infection and the results were significant. There was 100% survival amongst P. berghei infected mice treated with NSSF, NSOF and in combination with CQ, until the experiments were terminated 45 days later, while treatment with CQ had 60% survival rate.Note : The study was conducted in two phases. In the first phase, animals were selected randomly and placed in 4 groups; group 1 Nigella sativa seed plus feed (NSSF), group 2 NSSF + chloroquine (CQ), group 3 Nigella sativa oil extract in feed (NSOF) and group 4 NSOF + CQ. In the phase 2 experiments, mice were placed in 4 groups; groups 1 and 2 were given 5 mg/kg, 10 mg/kg doses of Nigella sativa oil extracts while groups 3 and 4 were given a combination of 5 mg/kg + CQ and 10 mg/kg + CQ respectively.
Part Used : น้ำมันActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 5 mg/kgDuration : -Type of interaction : PharmacokineticsInteraction with drug : Chloroquine*/Chloroquine sulphateDose/Conc.(drug) : 10 mg/kg body weight.Result : PositiveRemark : The 10 mg/kg oil group showed a better parasitaemia clearance than those treated with 5 mg/kg oil. However, both treatments took a longer time before parasite clearance was observed as compared to that of CQ alone. Combining 10 mg/kg oil extract CQ showed a faster parasite clearance than the CQ treated group. Four day suppressive observation showed 88, 78, 93 and 0% for 5 mg/kg, 10 mg/kg, 10 mg/kg + CQ and CQ, respectively. The combination with CQ produced a greater parasite suppression compared with either oil extract or CQ alone.Note : The study was conducted in two phases. In the first phase, animals were selected randomly and placed in 4 groups; group 1 Nigella sativa seed plus feed (NSSF), group 2 NSSF + chloroquine (CQ), group 3 Nigella sativa oil extract in feed (NSOF) and group 4 NSOF + CQ. In the phase 2 experiments, mice were placed in 4 groups; groups 1 and 2 were given 5 mg/kg, 10 mg/kg doses of Nigella sativa oil extracts while groups 3 and 4 were given a combination of 5 mg/kg + CQ and 10 mg/kg + CQ respectively.
Part Used : น้ำมันActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 10 mg/kgDuration : -Type of interaction : PharmacokineticsInteraction with drug : Chloroquine*/Chloroquine sulphateDose/Conc.(drug) : 10 mg/kg body weight.Result : PositiveRemark : The 10 mg/kg oil group showed a better parasitaemia clearance than those treated with 5 mg/kg oil. However, both treatments took a longer time before parasite clearance was observed as compared to that of CQ alone. Combining 10 mg/kg oil extract CQ showed a faster parasite clearance than the CQ treated group. Four day suppressive observation showed 88, 78, 93 and 0% for 5 mg/kg, 10 mg/kg, 10 mg/kg + CQ and CQ, respectively. The combination with CQ produced a greater parasite suppression compared with either oil extract or CQ alone.Note : The study was conducted in two phases. In the first phase, animals were selected randomly and placed in 4 groups; group 1 Nigella sativa seed plus feed (NSSF), group 2 NSSF + chloroquine (CQ), group 3 Nigella sativa oil extract in feed (NSOF) and group 4 NSOF + CQ. In the phase 2 experiments, mice were placed in 4 groups; groups 1 and 2 were given 5 mg/kg, 10 mg/kg doses of Nigella sativa oil extracts while groups 3 and 4 were given a combination of 5 mg/kg + CQ and 10 mg/kg + CQ respectively.
