ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : น้ำมันจากเมล็ด

Activity : ANTIINFLAMMATORY ACTIVITY, ANTIARTHRITIS, ANTIIRRITANT

Solvent/Active Compound : sunflower oil

Type of experiment : in vivo

Type of animal : rat

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : Non-specified

Dose/Conc.(herb) : -

Duration : -

Type of interaction : Pharmacodynamics

Interaction with drug : Indomethacin*/Indometacin

Dose/Conc.(drug) : -

Result : Positive

Remark :

Note : Result: When indomethacin given with sunflower, corn and olive oils reduced paw edema induced by carrageenan by 79.5%, 74.0% and 60.5%, whereas individual indomethacin and diclofenac reduced paw edema by 56.2% and 50.7%, resp. Besides, the administration of indomethacin together with the vegetable oils and alpha-tocopherol did not cause a statistically significant gastric damage in rats (P > 0.05). However, indomethacin caused statistically significant gastric lesions as compared with untreated rats (P < 0.05). These results suggest that indomethacin as well as other NSAIDs do not have any adverse effect on the gastrointestinal tract when they are used together with vetgetable oils and vitamin E or as the preparations of the oils.

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