| Synonym |
| Thai / English name |
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Single-blind trialN(Total) : 13N(Treatment) : 13Sex : MaleAge : 35 +/- 8 yrs.Route : Oral administrationDose/Conc.(herb) : 8 ozDuration : -Type of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : 2 mg (i.v.)Result : NegativeRemark : Subjects: healthy male volunteers participated in a randomized, single-dose, 5-way crossover study, with 1 week elapsing between trials. The 5 treatment groups were: 1. Intravenous (IV) midazolam (2 mg) preceded by water 2. Oral midazolam (6 mg) preceded by water 3. IV midazolam (2 mg) preceded by pomegranate juice 4. Oral midazolam (6 mg) preceded by pomegranate juice 5. Oral midazolam (6 mg) preceded by grapefruit juice Results: Pretreatment of volunteer subjects with pomegranate juice did not alter the elimination half-life, volume of distribution, or clearance of intravenous midazolam (2 mg). Administration of pomegranate juice also did not affect Cmax, total area under the curve (AUC), or clearance of oral midazolam (6 mg).
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 13N(Treatment) : 13Sex : MaleAge : 35 +/- 8 yrs.Route : Oral administrationDose/Conc.(herb) : 8 ozDuration : -Type of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : 2 mg (i.v.)Result : NegativeRemark : Subjects: healthy male volunteers participated in a randomized, single-dose, 5-way crossover study, with 1 week elapsing between trials. The 5 treatment groups were: 1. Intravenous (IV) midazolam (2 mg) preceded by water 2. Oral midazolam (6 mg) preceded by water 3. IV midazolam (2 mg) preceded by pomegranate juice 4. Oral midazolam (6 mg) preceded by pomegranate juice 5. Oral midazolam (6 mg) preceded by grapefruit juice Results: Pretreatment of volunteer subjects with pomegranate juice did not alter the elimination half-life, volume of distribution, or clearance of intravenous midazolam (2 mg). Administration of pomegranate juice also did not affect Cmax, total area under the curve (AUC), or clearance of oral midazolam (6 mg).
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Single-blind trialN(Total) : 13N(Treatment) : 13Sex : MaleAge : 35 +/- 8 yrs.Route : Oral administrationDose/Conc.(herb) : 8 ozDuration :Type of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : 6 mg (p.o.)Result : NegativeRemark : Subjects: healthy male volunteers participated in a randomized, single-dose, 5-way crossover study, with 1 week elapsing between trials. The 5 treatment groups were: 1. Intravenous (IV) midazolam (2 mg) preceded by water 2. Oral midazolam (6 mg) preceded by water 3. IV midazolam (2 mg) preceded by pomegranate juice 4. Oral midazolam (6 mg) preceded by pomegranate juice 5. Oral midazolam (6 mg) preceded by grapefruit juice Results: Pretreatment of volunteer subjects with pomegranate juice did not alter the elimination half-life, volume of distribution, or clearance of intravenous midazolam (2 mg). Administration of pomegranate juice also did not affect Cmax, total area under the curve (AUC), or clearance of oral midazolam (6 mg).
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 13N(Treatment) : 13Sex : MaleAge : 35 +/- 8 yrs.Route : Oral administrationDose/Conc.(herb) : 8 ozDuration :Type of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : 6 mg (p.o.)Result : NegativeRemark : Subjects: healthy male volunteers participated in a randomized, single-dose, 5-way crossover study, with 1 week elapsing between trials. The 5 treatment groups were: 1. Intravenous (IV) midazolam (2 mg) preceded by water 2. Oral midazolam (6 mg) preceded by water 3. IV midazolam (2 mg) preceded by pomegranate juice 4. Oral midazolam (6 mg) preceded by pomegranate juice 5. Oral midazolam (6 mg) preceded by grapefruit juice Results: Pretreatment of volunteer subjects with pomegranate juice did not alter the elimination half-life, volume of distribution, or clearance of intravenous midazolam (2 mg). Administration of pomegranate juice also did not affect Cmax, total area under the curve (AUC), or clearance of oral midazolam (6 mg).
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Case reportN(Total) : -N(Treatment) : -Sex : MaleAge : 48 yrs.Route : Oral administrationDose/Conc.(herb) : 200 ml twice weeklyDuration : 3 weeksType of interaction : PharmacokineticsInteraction with drug : RosuvastatinDose/Conc.(drug) : 5 mg/dayResult : PositiveRemark :Note : Pomergranate juice may increase the risk of rhabdomyolysis during rosuvastatin treatment
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 3 mL/kg/dayDuration : 1 weekType of interaction : PharmacokineticsInteraction with drug : NitrendipineDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : Type of experiment: *Rat in situ single-pass intestinal perfusion - There was a significant increase in effective permeability, absorption rate constant and fraction of drug absorbed in the pretreated group when compared with the control group, probably due to inhibition of the P-glycoprotein-mediated efflux of the drug by pomegranate juice (PJ). In comparison with control, PJ treatment significantly increased the area under the concentration-time curve of oral nitrendipine. The peak plasma concentration of nitrendipine was also significantly increased by PJ. However, elimination half-life of nitrendipine was not altered significantly in both PJ co-administered and pretreated groups. These results suggest that PJ inhibits the intestinal metabolism of nitrendipine without inhibiting the hepatic metabolism in rats.
Part Used : ผลActivity : DRUG INTERACTIONSolvent/Active Compound : methanolic extractType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : CiprofloxacinDose/Conc.(drug) : -Result : PositiveRemark :Note : Pomegranate pericarp extract enhances the antibacterial activity of ciprofloxacin against extended-spectrum beta-lactamase (ESBL) and metallo-beta-lactamase (MBL) producing Gram-negative bacilli.
Part Used : เนื้อหุ้มเมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : pomegranate juiceType of experiment : humanType of animal : -Type of study : Case reportN(Total) : 1N(Treatment) : 1Sex : MaleAge : 48 yrs.Route : Oral administrationDose/Conc.(herb) : -Duration : 3 wkType of interaction : PharmacodynamicsInteraction with drug : EzetimibeDose/Conc.(drug) : -Result : PositiveRemark : Pomegranate may increase the risk for rhabdomyolysis during statin therapy, as a result of intestinal CYP3A4 inhibition and increased absorption of active drugs, as commonly reported for grapefruit juice. One case report described a 48 y old man who developed rhabdomyolysis 3 wk after he began drinking pomegranate juice while taking ezetimibe and rosuvastatin for familial hypercholesterolemia.Note : Data from review
Part Used : เนื้อหุ้มเมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : pomegranate juiceType of experiment : humanType of animal : -Type of study : Case reportN(Total) : 1N(Treatment) : 1Sex : MaleAge : 48 yrs.Route : Oral administrationDose/Conc.(herb) : -Duration : 3 wkType of interaction : PharmacodynamicsInteraction with drug : RosuvastatinDose/Conc.(drug) : -Result : PositiveRemark : Pomegranate may increase the risk for rhabdomyolysis during statin therapy, as a result of intestinal CYP3A4 inhibition and increased absorption of active drugs, as commonly reported for grapefruit juice. One case report described a 48 y old man who developed rhabdomyolysis 3 wk after he began drinking pomegranate juice while taking ezetimibe and rosuvastatin for familial hypercholesterolemia.Note : Data from review
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 3 mLDuration : -Type of interaction : PharmacokineticsInteraction with drug : TolbutamideDose/Conc.(drug) : 20 mg/kgResult : PositiveRemark : Pomegranate juice increased tolbutamide bioavailability in rats.Note : Data incomplete
