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Part Used : น้ำจากผลActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 3 mL/kg/dayDuration : 1 weekType of interaction : PharmacokineticsInteraction with drug : NitrendipineDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : Type of experiment: *Rat in situ single-pass intestinal perfusion - There was a significant increase in effective permeability, absorption rate constant and fraction of drug absorbed in the pretreated group when compared with the control group, probably due to inhibition of the P-glycoprotein-mediated efflux of the drug by pomegranate juice (PJ). In comparison with control, PJ treatment significantly increased the area under the concentration-time curve of oral nitrendipine. The peak plasma concentration of nitrendipine was also significantly increased by PJ. However, elimination half-life of nitrendipine was not altered significantly in both PJ co-administered and pretreated groups. These results suggest that PJ inhibits the intestinal metabolism of nitrendipine without inhibiting the hepatic metabolism in rats.
Part Used : น้ำจากผลActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 3 mLDuration : -Type of interaction : PharmacokineticsInteraction with drug : TolbutamideDose/Conc.(drug) : 20 mg/kgResult : PositiveRemark : Pomegranate juice increased tolbutamide bioavailability in rats.Note : Data incomplete
Part Used : น้ำจากผลActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 2 mLDuration : -Type of interaction : PharmacokineticsInteraction with drug : Carbamazepine*/CBZDose/Conc.(drug) : 50 mg/kgResult : PositiveRemark : Pomegranate juice alters the carbamazepine pharmacokinetics in rats.Note : Data incomplete
Part Used : น้ำจากผลActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 2 mlDuration : 1 h before the oral administration of the carbamazepineType of interaction : PharmacokineticsInteraction with drug : Carbamazepine*/CBZDose/Conc.(drug) : 50 mg/kgResult : PositiveRemark : The area under the concentration-time curve (AUC) of carbamazepine was approximately 1.5-fold higher when pomegranate juice (2 ml) was orally injected 1 h before the oral administration of the carbamazepine (50 mg/kg). These data suggest that pomegranate juice component(s) impairs the function of enteric but not hepatic CYP3A. Thus, we discovered that a component(s) of pomegranate inhibits the human CYP3A-mediated metabolism of carbamazepine. Furthermore, pomegranate juice alters the carbamazepine pharmacokinetics in rats.Note : Data incomplete
