Synonym |
Thai / English name |
Part Used : เนื้อหุ้มเมล็ดActivity : MUSCLE EFFECTS(UNSPECIFIED)Solvent/Active Compound : pomegranate juiceType of experiment : humanType of animal : -Type of study : Case reportN(Total) : 1N(Treatment) : 1Sex : MaleAge : 48 yrs.Route : Oral administrationDose/Conc.(herb) : -Duration : 3 wkType of interaction : PharmacodynamicsInteraction with drug : EzetimibeDose/Conc.(drug) : -Result : PositiveRemark : Pomegranate may increase the risk for rhabdomyolysis during statin therapy, as a result of intestinal CYP3A4 inhibition and increased absorption of active drugs, as commonly reported for grapefruit juice. One case report described a 48 y old man who developed rhabdomyolysis 3 wk after he began drinking pomegranate juice while taking ezetimibe and rosuvastatin for familial hypercholesterolemia.Note : Data from review
Part Used : เนื้อหุ้มเมล็ดActivity : MUSCLE EFFECTS(UNSPECIFIED)Solvent/Active Compound : pomegranate juiceType of experiment : humanType of animal : -Type of study : Case reportN(Total) : 1N(Treatment) : 1Sex : MaleAge : 48 yrs.Route : Oral administrationDose/Conc.(herb) : -Duration : 3 wkType of interaction : PharmacodynamicsInteraction with drug : RosuvastatinDose/Conc.(drug) : -Result : PositiveRemark : Pomegranate may increase the risk for rhabdomyolysis during statin therapy, as a result of intestinal CYP3A4 inhibition and increased absorption of active drugs, as commonly reported for grapefruit juice. One case report described a 48 y old man who developed rhabdomyolysis 3 wk after he began drinking pomegranate juice while taking ezetimibe and rosuvastatin for familial hypercholesterolemia.Note : Data from review