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PUNICACEAE Punica granatum L. var. granatum

Synonym

none ...

Thai / English name

ทับทิม*

[1-6] of 6 article(s) found

หน้า 1

[1] POMEGRANATE JUICE DOES NOT IMPAIR CLEARANCE OF ORAL OR INTRAVENOUS MIDAZOLAM, A PROBE FOR CYTOCHROME P450-3A ACTIVITY: COMPARISON WITH GRAPEFRUIT JUICE.
FARKAS D,OLESON LE,ZHAO Y,ET AL.
J CLIN PHARMACOL 2007 Vol.47(3),286-94 $17053 [Full]

Part Used : น้ำจากผล
Activity : CYP3A INHIBITION

Solvent/Active Compound : -

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 0.05-2.5% (v/v)

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: human liver microsomes Results: For Alpha-OH-triazolam formation, the mean IC50 value for pomegranate juice (without preincubation of juice with microsomal protein) was 0.61 (+/-0.01)%. Preincubation of microsomes with pomegranate juice significantly increased the IC50 to 0.97 (+/-0.11)%, indicating a reduction of inhibitory potency due to preincubation.

[2] EFFECTS OF POMEGRANATE JUICE ON HUMAN CYTOCHROME P450 3A (CYP3A) AND CARBAMAZEPINE PHARMACOKINETICS IN RATS.
HIDAKA M,OKUMURA M,FUJITA K,ET AL.
DRUG METAB DISPOS 2005 Vol.33(5),644-8 372401 [Abstract]

Part Used : น้ำจากผล
Activity : CYP3A INHIBITION

Solvent/Active Compound : -

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 25 microlitre

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: human liver microsomes Pomegranate juice was shown to be a potent inhibitor of human CYP3A.

Note : Data incomplete

[3] INHIBITORY EFFECTS OF FRUIT JUICES ON CYP3A ACTIVITY.
KIM H,YOON Y-J,SHON J-H,ET AL.
DRUG METAB DISPOS 2006 Vol.34(4),521-3 373498 [Abstract]

Part Used : น้ำจากผล
Activity : CYP3A INHIBITION

Solvent/Active Compound : -

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: human liver microsomes The inhibitory potential of human CYP3A was in the order: grapefruit > black mulberry > wild grape > pomegranate > black raspberry.

Note : Data incomplete

[4] EFFECTS OF POMEGRANATE JUICE ON HUMAN CYTOCHROME P450 3A (CYP3A) AND CARBAMAZEPINE PHARMACOKINETICS IN RATS.
HIDAKA M,OKUMURA M,FUJITA K-I,ET AL.
DRUG METAB DISPOS 2005 Vol.33(5),644-8 373510 [Abstract]

Part Used : น้ำจากผล
Activity : CYP3A INHIBITION

Solvent/Active Compound : -

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 25 microlit (5.0%v/v)

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Carbamazepine*/CBZ
Dose/Conc.(drug) :

Result : Positive

Remark : Type of experiment: Human liver microsome Addition of 25 microl (5% v/v) of pomegranate juice resulted in almost complete inhibition of the carbamazepine 10,11-epoxidase activity of human CYP3A (1.8%).

Note : Data incomplete

[5] POTENT INHIBITION BY STAR FRUIT OF HUMAN CYTOCHROME P450 3A (CYP3A) ACTIVITY.
HIDAKA M,FUJITA K,OGIKUBO T,ET AL.
DRUG METAB DISPOS 2004 Vol.32(6),581-3 373520 [Abstract]

Part Used : น้ำจากผล
Activity : CYP3A INHIBITION

Solvent/Active Compound : -

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 0.2-6.0% (v/v)

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: human liver microsomes Among the tropical fruit juices tested (common papaw, dragon fruit, kiwi fruit, mango, passion fruit, pomegranate, rambutan, and star fruit), star fruit juice showed the most potent inhibition of CYP3A.

Note : Data incomplete

[6] POMEGRANATE JUICE EFFECTS ON CYTOCHROME P450S EXPRESSION: IN VIVO STUDIES.
FARIA A,MONTEIRO R,AZEVEDO I,ET AL.
J MED FOOD 2007 Vol.10(4),643-9 404120 [Abstract]

Part Used : น้ำจากผล
Activity : CYP3A INHIBITION

Solvent/Active Compound : -

Type of experiment : in vivo
Type of animal : mouse

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : -

Duration : 4 weeks
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Pomegranate juice consumption decreased total hepatic CYP content as well as the expression of CYP1A2 and CYP3A.

Note : Data incomplete

หน้า 1

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