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Thai / English name |
Part Used : น้ำจากผลActivity : CYTOCHROME P-450 INHIBITIONSolvent/Active Compound : -Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.05-2.5% (v/v)Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: human liver microsomes Results: For Alpha-OH-triazolam formation, the mean IC50 value for pomegranate juice (without preincubation of juice with microsomal protein) was 0.61 (+/-0.01)%. Preincubation of microsomes with pomegranate juice significantly increased the IC50 to 0.97 (+/-0.11)%, indicating a reduction of inhibitory potency due to preincubation.
Part Used : น้ำจากผลActivity : CYTOCHROME P-450 INHIBITIONSolvent/Active Compound : -Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: human liver microsomes Pomegranate juice was shown to be a potent inhibitor of human CYP2C9.Note : Data incomplete
Part Used : น้ำจากผลActivity : CYTOCHROME P-450 INHIBITIONSolvent/Active Compound : -Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 25 microlitreDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: human liver microsomes Pomegranate juice was shown to be a potent inhibitor of human CYP3A.Note : Data incomplete
Part Used : น้ำจากผลActivity : CYTOCHROME P-450 INHIBITIONSolvent/Active Compound : -Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: human liver microsomes The inhibitory potential of human CYP3A was in the order: grapefruit > black mulberry > wild grape > pomegranate > black raspberry.Note : Data incomplete
Part Used : น้ำจากผลActivity : CYTOCHROME P-450 INHIBITIONSolvent/Active Compound : -Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 25 microlit (5.0%v/v)Duration : -Type of interaction : PharmacokineticsInteraction with drug : Carbamazepine*/CBZDose/Conc.(drug) :Result : PositiveRemark : Type of experiment: Human liver microsome Addition of 25 microl (5% v/v) of pomegranate juice resulted in almost complete inhibition of the carbamazepine 10,11-epoxidase activity of human CYP3A (1.8%).Note : Data incomplete
Part Used : น้ำจากผลActivity : CYTOCHROME P-450 INHIBITIONSolvent/Active Compound : -Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.2-6.0% (v/v)Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: human liver microsomes Among the tropical fruit juices tested (common papaw, dragon fruit, kiwi fruit, mango, passion fruit, pomegranate, rambutan, and star fruit), star fruit juice showed the most potent inhibition of CYP3A.Note : Data incomplete
Part Used : น้ำจากผลActivity : CYTOCHROME P-450 INHIBITIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : 4 weeksType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Pomegranate juice consumption decreased total hepatic CYP content as well as the expression of CYP1A2 and CYP3A.Note : Data incomplete