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Part Used : น้ำจากผลActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 2 mLDuration : -Type of interaction : PharmacokineticsInteraction with drug : Carbamazepine*/CBZDose/Conc.(drug) : 50 mg/kgResult : PositiveRemark : Pomegranate juice alters the carbamazepine pharmacokinetics in rats.Note : Data incomplete
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 2 mLDuration : -Type of interaction : PharmacokineticsInteraction with drug : Carbamazepine*/CBZDose/Conc.(drug) : 50 mg/kgResult : PositiveRemark : Pomegranate juice alters the carbamazepine pharmacokinetics in rats.Note : Data incomplete
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 25 microlit (5.0%v/v)Duration : -Type of interaction : PharmacokineticsInteraction with drug : Carbamazepine*/CBZDose/Conc.(drug) :Result : PositiveRemark : Type of experiment: Human liver microsome Addition of 25 microl (5% v/v) of pomegranate juice resulted in almost complete inhibition of the carbamazepine 10,11-epoxidase activity of human CYP3A (1.8%).Note : Data incomplete
Part Used : น้ำจากผลActivity : CYTOCHROME P-450 INHIBITIONSolvent/Active Compound : -Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 25 microlit (5.0%v/v)Duration : -Type of interaction : PharmacokineticsInteraction with drug : Carbamazepine*/CBZDose/Conc.(drug) :Result : PositiveRemark : Type of experiment: Human liver microsome Addition of 25 microl (5% v/v) of pomegranate juice resulted in almost complete inhibition of the carbamazepine 10,11-epoxidase activity of human CYP3A (1.8%).Note : Data incomplete
Part Used : น้ำจากผลActivity : CYP3A INHIBITIONSolvent/Active Compound : -Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 25 microlit (5.0%v/v)Duration : -Type of interaction : PharmacokineticsInteraction with drug : Carbamazepine*/CBZDose/Conc.(drug) :Result : PositiveRemark : Type of experiment: Human liver microsome Addition of 25 microl (5% v/v) of pomegranate juice resulted in almost complete inhibition of the carbamazepine 10,11-epoxidase activity of human CYP3A (1.8%).Note : Data incomplete
Part Used : น้ำจากผลActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 2 mlDuration : 1 h before the oral administration of the carbamazepineType of interaction : PharmacokineticsInteraction with drug : Carbamazepine*/CBZDose/Conc.(drug) : 50 mg/kgResult : PositiveRemark : The area under the concentration-time curve (AUC) of carbamazepine was approximately 1.5-fold higher when pomegranate juice (2 ml) was orally injected 1 h before the oral administration of the carbamazepine (50 mg/kg). These data suggest that pomegranate juice component(s) impairs the function of enteric but not hepatic CYP3A. Thus, we discovered that a component(s) of pomegranate inhibits the human CYP3A-mediated metabolism of carbamazepine. Furthermore, pomegranate juice alters the carbamazepine pharmacokinetics in rats.Note : Data incomplete
