ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

LEGUMINOSAE (FABACEAE) - PAPILIONOIDEAE Glycine max (L.) Merr.

Synonym

LEGUMINOSAE (FABACEAE) - PAPILIONOIDEAE Glycine hispida Maxim.

Thai / English name

ถั่วเหลือง*

[1-3] of 3 article(s) found

หน้า 1

[1] INTERACTIONS BETWEEN HERBAL AND CONVENTIONAL MEDICINES: THE ROLE OF CYTOCHROME P450 ENZYMES AND P-GLYCOPROTEIN.
WILLIAMSON EM
PHARMACOLOGYONLINE 2006 Vol.2(),200-5 $29296 [Full]

Part Used : ไม่ระบุ
Activity : P-GLYCOPROTEIN INHIBITION

Solvent/Active Compound : Genistein

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Tamoxifen*/TAM
Dose/Conc.(drug) : -

Result : Positive

Remark : No clinical reports, and conflicting evidence between effects of genistein, an isolated ingredient, and the total extract of soya. Genistein inhibits various CYP enzymes and P-gp, but soya extract does not affect CYP3A4. Theoretical considerations suggest avoidance with HRT, also tamoxifen and other treatments for breast cancer.

Note : Data incomplete, data from review article.

[2] INTERACTIONS BETWEEN HERBAL AND CONVENTIONAL MEDICINES: THE ROLE OF CYTOCHROME P450 ENZYMES AND P-GLYCOPROTEIN.
WILLIAMSON EM
PHARMACOLOGYONLINE 2006 Vol.(2),200-5 $56391 [Full]

Part Used : ไม่ระบุ
Activity : P-GLYCOPROTEIN INHIBITION

Solvent/Active Compound : genistein

Type of experiment : non specified
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : No clinical reports, and conlicting evidence between effects of genistein, an isolated ingredient, and the total extract of soya. Genistein inhibits various CYP enzymes and P-gp, but soya extract does NOT affect CYP3A4. Theoretical considerations suggest avoidance with HRT, also tamoxifen and other treatments for breast cancer.

Note : Data from review, data incomplete.

[3] INHIBITORY EFFECT OF A BITTER MELON EXTRACT ON THE P-GLYCOPROTEIN ACTIVITY IN INTESTINAL CACO-2 CELLS.
KONISHI T,SATSU H,HATSUGAI Y,ET AL.
BR J PHARMACOL 2004 Vol.143(3),379-87 277244 [Abstract]

Part Used : ไม่ระบุ
Activity : P-GLYCOPROTEIN INHIBITION

Solvent/Active Compound : 40% methanol

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: Caco-2 cells Results: Extracts of soybean, dokudami and welsh onion by 40% methanol inhibitied P-glycoprotein.

Note : Data incomplete

หน้า 1

EN

Web Link ที่เกี่ยวข้อง

ที่อยู่