ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : เมล็ด

Activity : CYP3A4/5 INHIBITION

Solvent/Active Compound : s-equol

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : -

Duration : -

Type of interaction : Pharmacokinetics

Interaction with drug : -

Dose/Conc.(drug) : -

Result : Negative

Remark : S-equol had little or no effect on the activity of these enzymes whereas the selective prototype inhibitors demonstrated potent inhibition. Based on the inhibitory profile, it is unlikely that S-equol will have any effects on plasma concentration or therapeutic acticity of co-administered drugs metabolized by CYP1A2, CYP2C9/19, CYP2D6 and CYP3A4/5.

---