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| Thai / English name |
Part Used : เมล็ดActivity : CYP2E1 INHIBITIONSolvent/Active Compound : GenistineType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 50 mg/BWkgDuration : -Type of interaction : PharmacokineticsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) : 200 mg/BWkgResult : PositiveRemark : The activity of CYP2E1 was not significant difference between control and Gen 3 group. The APAP increased activity of CYP2E1 with substantially more than the control and Gen3 groups, and there was a significant change in APAP administered with or without genistein. Genistein suppressed the activities induced by APAP, exhibiting dose-dependent effects.Note : Mice were divided into six groups: the control group (untreated, control check), the reagent control group (Gen treatment at 200 mg/BWkg i.g., named as Gen3), the APAP group (200 mg/BWkg i.g.), the APAP (200 mg/BWkg i.g.) + Gen1 (50 mg/BWkg i.g.) group, the APAP + Gen2 (100 mg/BWkg i.g.) group and the APAP + Gen3 (200 mg/BWkg) group. Ten mice from every group were obtained blood and liver for 16 h after treatment.
Part Used : เมล็ดActivity : CYP2E1 INHIBITIONSolvent/Active Compound : GenistineType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 100 mg/BWkgDuration : -Type of interaction : PharmacokineticsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) : 200 mg/BWkgResult : PositiveRemark : The activity of CYP2E1 was not significant difference between control and Gen 3 group. The APAP increased activity of CYP2E1 with substantially more than the control and Gen3 groups, and there was a significant change in APAP administered with or without genistein. Genistein suppressed the activities induced by APAP, exhibiting dose-dependent effects.Note : Mice were divided into six groups: the control group (untreated, control check), the reagent control group (Gen treatment at 200 mg/BWkg i.g., named as Gen3), the APAP group (200 mg/BWkg i.g.), the APAP (200 mg/BWkg i.g.) + Gen1 (50 mg/BWkg i.g.) group, the APAP + Gen2 (100 mg/BWkg i.g.) group and the APAP + Gen3 (200 mg/BWkg) group. Ten mice from every group were obtained blood and liver for 16 h after treatment.
Part Used : เมล็ดActivity : CYP2E1 INHIBITIONSolvent/Active Compound : GenistineType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 200 mg/BWkgDuration : -Type of interaction : PharmacokineticsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) : 200 mg/BWkgResult : PositiveRemark : The activity of CYP2E1 was not significant difference between control and Gen 3 group. The APAP increased activity of CYP2E1 with substantially more than the control and Gen3 groups, and there was a significant change in APAP administered with or without genistein. Genistein suppressed the activities induced by APAP, exhibiting dose-dependent effects.Note : Mice were divided into six groups: the control group (untreated, control check), the reagent control group (Gen treatment at 200 mg/BWkg i.g., named as Gen3), the APAP group (200 mg/BWkg i.g.), the APAP (200 mg/BWkg i.g.) + Gen1 (50 mg/BWkg i.g.) group, the APAP + Gen2 (100 mg/BWkg i.g.) group and the APAP + Gen3 (200 mg/BWkg) group. Ten mice from every group were obtained blood and liver for 16 h after treatment.
