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Part Used : เมล็ดActivity : CYP2C19 INHIBITIONSolvent/Active Compound : s-equolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : S-equol had little or no effect on the activity of these enzymes whereas the selective prototype inhibitors demonstrated potent inhibition. Based on the inhibitory profile, it is unlikely that S-equol will have any effects on plasma concentration or therapeutic acticity of co-administered drugs metabolized by CYP1A2, CYP2C9/19, CYP2D6 and CYP3A4/5.