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LEGUMINOSAE (FABACEAE) - PAPILIONOIDEAE Glycine max (L.) Merr.

Synonym

LEGUMINOSAE (FABACEAE) - PAPILIONOIDEAE Glycine hispida Maxim.

Thai / English name

ถั่วเหลือง*

[1-2] of 2 article(s) found

หน้า 1

[1] TOXICOKINETICS AND LACK OF UTEROTROPIC EFFECT OF ORALLY ADMINISTERED S-EQUOL.
RICHARD J. SCHWEN,LINH NGUYEN,JEFFREY B. PLOMLEY,ET AL.
FOOD CHEM TOXICOL 2012 Vol.50(),1741-8 $40306 [Full]

Part Used : เมล็ด
Activity : CYP1A2 INHIBITION

Solvent/Active Compound : s-equol

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : S-equol had little or no effect on the activity of these enzymes whereas the selective prototype inhibitors demonstrated potent inhibition. Based on the inhibitory profile, it is unlikely that S-equol will have any effects on plasma concentration or therapeutic acticity of co-administered drugs metabolized by CYP1A2, CYP2C9/19, CYP2D6 and CYP3A4/5.

[2] EFFECT OF DAIDZEIN ON CYP1A2 ACTIVITY AND PHARMACOKINETICS OF THEOPHYLLINE IN HEALTHY VOLUNTEERS.
WEN-XING PENG,HUAN-DE LI,HONG-HAO ZHOU
EUR J CLIN PHARMACOL 2003 Vol.59(),237-41 $56509 [Full]

Part Used : เมล็ด
Activity : CYP1A2 INHIBITION

Solvent/Active Compound : daidzein

Type of experiment : human
Type of animal : -

Type of study : Single-blind trial

N(Total) : 20 (M/F = 10/10)
N(Treatment) : 10

Sex : Both sex
Age : 22-28 yrs. (mean 25)

Route : Oral administration
Dose/Conc.(herb) : 200 mg daidzein twice daily

Duration : 10 days
Type of interaction : Pharmacokinetics

Interaction with drug : Caffeine
Dose/Conc.(drug) : -

Result : Positive

Remark : The caffeine metabolic ratio (CMR) used as an indicator of CYP1A2 function. Result: The baseline value of CMR between test group and control group did not show a difference (P=0.215). The percentage decrease in CMR ranged from -50% to 20%, with an average value of -19.8+/-19.7%. The percentage decrease in test group was statistically significant (P=0.009), and no significant changes were shown in the control group (t=0.12, P=0.914).

Note : Type of study: A single-blind, placebo-controlled, parallel study

หน้า 1

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