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LEGUMINOSAE (FABACEAE) - PAPILIONOIDEAE Glycine max (L.) Merr.

Synonym

LEGUMINOSAE (FABACEAE) - PAPILIONOIDEAE Glycine hispida Maxim.

Thai / English name

ถั่วเหลือง*

[1-4] of 4 article(s) found

หน้า 1

[1] INTERACTIONS BETWEEN HERBAL AND CONVENTIONAL MEDICINES: THE ROLE OF CYTOCHROME P450 ENZYMES AND P-GLYCOPROTEIN.
WILLIAMSON EM
PHARMACOLOGYONLINE 2006 Vol.2(),200-5 $29296 [Full]

Part Used : ไม่ระบุ
Activity : CYTOCHROME P-450 INHIBITION

Solvent/Active Compound : Genistein

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Tamoxifen*/TAM
Dose/Conc.(drug) : -

Result : Positive

Remark : No clinical reports, and conflicting evidence between effects of genistein, an isolated ingredient, and the total extract of soya. Genistein inhibits various CYP enzymes and P-gp, but soya extract does not affect CYP3A4. Theoretical considerations suggest avoidance with HRT, also tamoxifen and other treatments for breast cancer.

Note : Data incomplete, data from review article.

[2] INTERACTIONS BETWEEN HERBAL AND CONVENTIONAL MEDICINES: THE ROLE OF CYTOCHROME P450 ENZYMES AND P-GLYCOPROTEIN.
WILLIAMSON EM
PHARMACOLOGYONLINE 2006 Vol.(2),200-5 $56391 [Full]

Part Used : ไม่ระบุ
Activity : CYTOCHROME P-450 INHIBITION

Solvent/Active Compound : genistein

Type of experiment : non specified
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : No clinical reports, and conlicting evidence between effects of genistein, an isolated ingredient, and the total extract of soya. Genistein inhibits various CYP enzymes and P-gp, but soya extract does NOT affect CYP3A4. Theoretical considerations suggest avoidance with HRT, also tamoxifen and other treatments for breast cancer.

Note : Data from review, data incomplete.

[3] CYTOCHROME P450 2A INHIBITORS CONTAINING SOYBEAN SAPONIN AND/OR GLYCYRRHIZA EXTRACTS.
KAMATAKI T
JPN KOKAI TOKKYO KOHO JP 2006169186 2006 Vol.(),6pp 317069 [Abstract]

Part Used : เมล็ด
Activity : CYTOCHROME P-450 INHIBITION

Solvent/Active Compound : saponin

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark :

Note : Data incomplete.

[4] REDUCTION IN 7,12-DIMETHYLBENZ[A]ANTHRACENE-INDUCED HEPATIC CYTOCHROME-P450 1A1 EXPRESSION FOLLOWING SOY CONSUMPTION IN FEMALE RATS IS MEDIATED BY DEGRADATION OF THE ARYL HYDROCARBON RECEPTOR.
SINGHAL R,BADGER TM,RONIS MJ
J NUTR 2007 Vol.137(1),19-24 337071 [Abstract]

Part Used : ไม่ระบุ
Activity : CYTOCHROME P-450 INHIBITION

Solvent/Active Compound : soybean protein isolate (SPI)

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Decreased 7,12-dimethylbenz[a]anthracene induced hepatic cytochrome-P 450 1A1 (CYP1A1), apoprotein, and mRNA expression were found along with decreased binding of aryl hydrocarbon receptor (AhR)-AhR nuclear translocator complex to CYP1A1 gene promoter in SPI + rats compared with casein- or SPI-rats.

Note : Data incomplete

หน้า 1

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