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Part Used : เมล็ดActivity : CYP3A2 INDUCTIONSolvent/Active Compound : Soy isoflavoneType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 300 mg of isoflavone/kg of dietDuration : 4 weeksType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Soy isoflavone did not affect the mRNA abundance of all CYPS.Note : Soy isoflavones. A fermented soybean extract (FSBE) rich in the two major isoflavone aglycones, genistein and daidzein. This FSBE contained 155 mg/g of genistein, 127 mg/g of daidzein, 18 mg/g of glycitein and less than 1 mg/g of genistin, daidzin and glycytin.
Part Used : เมล็ดActivity : CYP3A2 INDUCTIONSolvent/Active Compound : Soy isoflavoneType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 100 mg of isoflavone/kg of dietDuration : 4 weeksType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The gene expression of CYP2C11 and CYP3A2 from the female rats was at a much lower level than that of the male rats. Dietary isoflavone significantly decreased the gene expression of CYP3A2 and decreased the gene expression of CYP2C11 in the female rats, although there was no significant difference among the groups (P = 0.056775). Dietary isoflavone did not significantly affect the gene expression of the other CYPs in the male and female rats.Note : Soy isoflavones. A fermented soybean extract (FSBE) rich in the two major isoflavone aglycones, genistein and daidzein. This FSBE contained 155 mg/g of genistein, 127 mg/g of daidzein, 18 mg/g of glycitein and less than 1 mg/g of genistin, daidzin and glycytin.
Part Used : เมล็ดActivity : CYP3A2 INDUCTIONSolvent/Active Compound : Soy isoflavoneType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 200 mg of isoflavone/kg of dietDuration : 4 weeksType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The gene expression of CYP2C11 and CYP3A2 from the female rats was at a much lower level than that of the male rats. Dietary isoflavone significantly decreased the gene expression of CYP3A2 and decreased the gene expression of CYP2C11 in the female rats, although there was no significant difference among the groups (P = 0.056775). Dietary isoflavone did not significantly affect the gene expression of the other CYPs in the male and female rats.Note : Soy isoflavones. A fermented soybean extract (FSBE) rich in the two major isoflavone aglycones, genistein and daidzein. This FSBE contained 155 mg/g of genistein, 127 mg/g of daidzein, 18 mg/g of glycitein and less than 1 mg/g of genistin, daidzin and glycytin.
Part Used : เมล็ดActivity : CYP3A2 INDUCTIONSolvent/Active Compound : Soy isoflavoneType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 300 mg of isoflavone/kg of dietDuration : 4 weeksType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The gene expression of CYP2C11 and CYP3A2 from the female rats was at a much lower level than that of the male rats. Dietary isoflavone significantly decreased the gene expression of CYP3A2 and decreased the gene expression of CYP2C11 in the female rats, although there was no significant difference among the groups (P = 0.056775). Dietary isoflavone did not significantly affect the gene expression of the other CYPs in the male and female rats.Note : Soy isoflavones. A fermented soybean extract (FSBE) rich in the two major isoflavone aglycones, genistein and daidzein. This FSBE contained 155 mg/g of genistein, 127 mg/g of daidzein, 18 mg/g of glycitein and less than 1 mg/g of genistin, daidzin and glycytin.
Part Used : เมล็ดActivity : CYP3A2 INDUCTIONSolvent/Active Compound : Soybean protein isolated (SPI)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Consumption of SPI without inducer treatment reulted in the expression of CYP3A1 (CYP3A23), and CYP3A2 mRNAs, expression of CYP3A apoprotein in hepatic microsomes, and a 2-fold greater turnover of the CYP3A substrate midazolam. Induced CYP3A1, CYP3A2, and CYP3A9, but not CYP3A18 mRNA expression in rats fed both diets. Hepatic CYP3A apoprotein expression and midazolam 4-hydroxylation in SPI-fed rats was greater than that of fed rats after DEX treatment. Also induced CYP3A2 mRNA 2-fold in rats fed both diets but CYP3A apoprotein expression in microsomes from SPI-fed CLT rats was double that of CLT-treated rats fed CAS.Note : Data incomplete. Rats were gavaged with corn oil or one of the CYP3A inducers, dexamethasone (DEX) and clotrimazole (CLT), at a dose of 50 mg/kg. CAS=Casein
Part Used : เมล็ดActivity : CYP3A2 INDUCTIONSolvent/Active Compound : caseinType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Analysis of heterologous nuclear RNA expression by RT-PCR using intron-specific primers for CYP3A1 revealed a 14-fold increase in RNA transcription in CAS-fed rats after treatment with DEX but no increase in rats fed SPI compared with rats fed CAS even though CYP3A1 mRNA and CYP3A apoprotein were significantly elevated.Note : Data incomplete. Rats were gavaged with corn oil or one of the CYP3A inducers, dexamethasone (DEX) and clotrimazole (CLT), at a dose of 50 mg/kg. CAS=Casein
Part Used : ไม่ระบุActivity : CYP3A2 INDUCTIONSolvent/Active Compound : soy proteinType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : These data suggest that early soy consumption may increase the metabolism of a wide variety of CYP3A substrates, but that soy does not imprint the expression of CYP3A enzymes. Effects on CYP3A1 expression appear to be primarily due to phytochemical components of SPI other than isoflavones. In contrast, consumption of soy protein and daidzein appear to be associated with the induction of CYP3A2.Note : Data from abstract
