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Part Used : เมล็ดActivity : CYP3A INDUCTIONSolvent/Active Compound : SoymilkType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 4.0 g/kg of soymilk powdersDuration : *Type of interaction : PharmacokineticsInteraction with drug : Ciclosporin*/Cyclosporin/Cyclosporin A/Cyclosporine/CsA/CyADose/Conc.(drug) : -Result : PositiveRemark : Result: soymilk significantly decreased the Cmax of CSP by 64.5%, and reduced the AUC0-540 by 64.9%. Mechanism studies revealed that the activities of P-gp and CYP3A4 were induced by soymilk. Conculsion, ingestion of soymilk significantly activated the functions of P-gp and CYP3A.Note : Cyclosporine (CSP), an immunosuppressant agent, is a substrate of P-gp and CYP3A4. *Duration: CSP was given to the rats at 2.5 mg/kg with and without a concomitant dose of miso or soymilk powders in crossover designs. Blood samples were withdrawn via cardiopuncture at 20, 40, 60, 180, 300 and 540 min after dosing with CSP.
Part Used : เมล็ดActivity : CYP3A INDUCTIONSolvent/Active Compound : MisoType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 2.0 g/kg of misoDuration : *Type of interaction : PharmacokineticsInteraction with drug : Ciclosporin*/Cyclosporin/Cyclosporin A/Cyclosporine/CsA/CyADose/Conc.(drug) : -Result : PositiveRemark : Result: Miso significantly decreased the Cmax of CSP by 78.3%, and reduced the AUC0-540 by 78.3%, respectively. Mechanism studies revealed that the activities of P-gp and CYP3A4 were induced by miso. Conclusion, ingestion of miso significantly activated the functions of P-gp and CYP3A.Note : Cyclosporine (CSP), an immunosuppressant agent, is a substrate of P-gp and CYP3A4. *Duration: CSP was given to the rats at 2.5 mg/kg with and without a concomitant dose of miso or soymilk powders in crossover designs. Blood samples were withdrawn via cardiopuncture at 20, 40, 60, 180, 300 and 540 min after dosing with CSP.
Part Used : เมล็ดActivity : CYP3A INDUCTIONSolvent/Active Compound : Soybean protein isolated (SPI)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Consumption of SPI without inducer treatment reulted in the expression of CYP3A1 (CYP3A23), and CYP3A2 mRNAs, expression of CYP3A apoprotein in hepatic microsomes, and a 2-fold greater turnover of the CYP3A substrate midazolam. Induced CYP3A1, CYP3A2, and CYP3A9, but not CYP3A18 mRNA expression in rats fed both diets. Hepatic CYP3A apoprotein expression and midazolam 4-hydroxylation in SPI-fed rats was greater than that of fed rats after DEX treatment. Also induced CYP3A2 mRNA 2-fold in rats fed both diets but CYP3A apoprotein expression in microsomes from SPI-fed CLT rats was double that of CLT-treated rats fed CAS.Note : Data incomplete. Rats were gavaged with corn oil or one of the CYP3A inducers, dexamethasone (DEX) and clotrimazole (CLT), at a dose of 50 mg/kg. CAS=Casein
Part Used : เมล็ดActivity : CYP3A INDUCTIONSolvent/Active Compound : caseinType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Analysis of heterologous nuclear RNA expression by RT-PCR using intron-specific primers for CYP3A1 revealed a 14-fold increase in RNA transcription in CAS-fed rats after treatment with DEX but no increase in rats fed SPI compared with rats fed CAS even though CYP3A1 mRNA and CYP3A apoprotein were significantly elevated.Note : Data incomplete. Rats were gavaged with corn oil or one of the CYP3A inducers, dexamethasone (DEX) and clotrimazole (CLT), at a dose of 50 mg/kg. CAS=Casein
