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Part Used : เมล็ดActivity : CYTOCHROME P-450 INDUCTIONSolvent/Active Compound : s-equolType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 25-500 mg/kg body weightDuration : 28 daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Male rats showed a slight but insignificant decrease in total cytochrome P450 content at the 500 mg/kg dose compared to the vehicle treated group, thus the 25 and 125 mg/kg groups were not analyzed. Female rats showed a statistically significant increase (26%), but only at the highest dose tested.
Part Used : เมล็ดActivity : CYTOCHROME P-450 INDUCTIONSolvent/Active Compound : s-equolType of experiment : in vivoType of animal : otherType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 25-1000 mg/kg body weightDuration : 28 daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Type of animal = monkey In male monkeys treated for 28 days with S-equol, a significant increase in total cytochrome P450 content in livers was observed at the 250 mg/kg dose (30% increase) and at 1000 mg/kg (40% increase). No increases in cytochrome P450 content were observed in female cynomolgus monkeys at any dose tested.
Part Used : เมล็ดActivity : CYTOCHROME P-450 INDUCTIONSolvent/Active Compound : Soy isoflavoneType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 300 mg of isoflavone/kg of dietDuration : 4 weeksType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Soy isoflavone did not affect the mRNA abundance of all CYPS.Note : Soy isoflavones. A fermented soybean extract (FSBE) rich in the two major isoflavone aglycones, genistein and daidzein. This FSBE contained 155 mg/g of genistein, 127 mg/g of daidzein, 18 mg/g of glycitein and less than 1 mg/g of genistin, daidzin and glycytin.
Part Used : เมล็ดActivity : CYTOCHROME P-450 INDUCTIONSolvent/Active Compound : Soy isoflavoneType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 100 mg of isoflavone/kg of dietDuration : 4 weeksType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The gene expression of CYP2C11 and CYP3A2 from the female rats was at a much lower level than that of the male rats. Dietary isoflavone significantly decreased the gene expression of CYP3A2 and decreased the gene expression of CYP2C11 in the female rats, although there was no significant difference among the groups (P = 0.056775). Dietary isoflavone did not significantly affect the gene expression of the other CYPs in the male and female rats.Note : Soy isoflavones. A fermented soybean extract (FSBE) rich in the two major isoflavone aglycones, genistein and daidzein. This FSBE contained 155 mg/g of genistein, 127 mg/g of daidzein, 18 mg/g of glycitein and less than 1 mg/g of genistin, daidzin and glycytin.
Part Used : เมล็ดActivity : CYTOCHROME P-450 INDUCTIONSolvent/Active Compound : Soy isoflavoneType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 200 mg of isoflavone/kg of dietDuration : 4 weeksType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The gene expression of CYP2C11 and CYP3A2 from the female rats was at a much lower level than that of the male rats. Dietary isoflavone significantly decreased the gene expression of CYP3A2 and decreased the gene expression of CYP2C11 in the female rats, although there was no significant difference among the groups (P = 0.056775). Dietary isoflavone did not significantly affect the gene expression of the other CYPs in the male and female rats.Note : Soy isoflavones. A fermented soybean extract (FSBE) rich in the two major isoflavone aglycones, genistein and daidzein. This FSBE contained 155 mg/g of genistein, 127 mg/g of daidzein, 18 mg/g of glycitein and less than 1 mg/g of genistin, daidzin and glycytin.
Part Used : เมล็ดActivity : CYTOCHROME P-450 INDUCTIONSolvent/Active Compound : Soy isoflavoneType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 300 mg of isoflavone/kg of dietDuration : 4 weeksType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The gene expression of CYP2C11 and CYP3A2 from the female rats was at a much lower level than that of the male rats. Dietary isoflavone significantly decreased the gene expression of CYP3A2 and decreased the gene expression of CYP2C11 in the female rats, although there was no significant difference among the groups (P = 0.056775). Dietary isoflavone did not significantly affect the gene expression of the other CYPs in the male and female rats.Note : Soy isoflavones. A fermented soybean extract (FSBE) rich in the two major isoflavone aglycones, genistein and daidzein. This FSBE contained 155 mg/g of genistein, 127 mg/g of daidzein, 18 mg/g of glycitein and less than 1 mg/g of genistin, daidzin and glycytin.
Part Used : น้ำมันActivity : CYTOCHROME P-450 INDUCTIONSolvent/Active Compound : Polysaccharides*Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Solvent/active compound: *5, 10, 25, 50, 100 microgram/ml from soybeans and soybeans fermentedNote : Data from abstract
Part Used : ไม่ระบุActivity : CYTOCHROME P-450 INDUCTIONSolvent/Active Compound : soy proteinType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : These data suggest that early soy consumption may increase the metabolism of a wide variety of CYP3A substrates, but that soy does not imprint the expression of CYP3A enzymes. Effects on CYP3A1 expression appear to be primarily due to phytochemical components of SPI other than isoflavones. In contrast, consumption of soy protein and daidzein appear to be associated with the induction of CYP3A2.Note : Data from abstract
Part Used : น้ำมันActivity : CYTOCHROME P-450 INDUCTIONSolvent/Active Compound : -Type of experiment : in vitroType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Rat liver microsomesNote : Data from abstract
Part Used : น้ำมันActivity : CYTOCHROME P-450 INDUCTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 15% soybean oil in dietDuration : 8 weeksType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Cytochrome P450 content was significant higher in the soybean group than in the tallow group, after the 25-mg of 2-acetylaminofluorene injections, and the 100 mg injections results in lower cytochrome P450 and higher cytochrome B5 content in soybean group.Note : Data incomplete.
