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LEGUMINOSAE (FABACEAE) - PAPILIONOIDEAE Glycine max (L.) Merr.

Synonym

LEGUMINOSAE (FABACEAE) - PAPILIONOIDEAE Glycine hispida Maxim.

Thai / English name

ถั่วเหลือง*

[1-2] of 2 article(s) found

หน้า 1

[1] INTERACTIONS BETWEEN HERBAL AND CONVENTIONAL MEDICINES: THE ROLE OF CYTOCHROME P450 ENZYMES AND P-GLYCOPROTEIN.
WILLIAMSON EM
PHARMACOLOGYONLINE 2006 Vol.2(),200-5 $29296 [Full]

Part Used : ไม่ระบุ
Activity : CYTOCHROME P-450 INHIBITION

Solvent/Active Compound : Genistein

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Tamoxifen*/TAM
Dose/Conc.(drug) : -

Result : Positive

Remark : No clinical reports, and conflicting evidence between effects of genistein, an isolated ingredient, and the total extract of soya. Genistein inhibits various CYP enzymes and P-gp, but soya extract does not affect CYP3A4. Theoretical considerations suggest avoidance with HRT, also tamoxifen and other treatments for breast cancer.

Note : Data incomplete, data from review article.

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : Genistein

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Tamoxifen*/TAM
Dose/Conc.(drug) : -

Result : Positive

Remark : No clinical reports, and conflicting evidence between effects of genistein, an isolated ingredient, and the total extract of soya. Genistein inhibits various CYP enzymes and P-gp, but soya extract does not affect CYP3A4. Theoretical considerations suggest avoidance with HRT, also tamoxifen and other treatments for breast cancer.

Note : Data incomplete, data from review article.

Part Used : ไม่ระบุ
Activity : P-GLYCOPROTEIN INHIBITION

Solvent/Active Compound : Genistein

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Tamoxifen*/TAM
Dose/Conc.(drug) : -

Result : Positive

Remark : No clinical reports, and conflicting evidence between effects of genistein, an isolated ingredient, and the total extract of soya. Genistein inhibits various CYP enzymes and P-gp, but soya extract does not affect CYP3A4. Theoretical considerations suggest avoidance with HRT, also tamoxifen and other treatments for breast cancer.

Note : Data incomplete, data from review article.

[2] NATURAL REMEDIES AND HORMONE PREPARATIONS--POTENTIAL RISK FOR BREAST CANCER PATIENTS. A STUDY SURVEYS THE USE OF AGENTS WHICH POSSIBLY COUNTERACT WITH THE TREATMENT.
MALEKZADEH F,ROSE C,INGVAR C,ET AL.
LAKARTIDNINGEN 2005 Vol.102(44),3226-8, 3230-1 407149 [Abstract]

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : -

Type of experiment : human
Type of animal : -

Type of study : Cross-section

N(Total) : 233
N(Treatment) : -

Sex : Female
Age : -

Route : Oral administration
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Tamoxifen*/TAM
Dose/Conc.(drug) : -

Result : Positive

Remark : The study identified use of 35 different typed of complimentary alternative medicine products and seven of these could potentially increase the risk of breast cancer or interact with tamoxifen or aromatase inhibitiors: soy, garlic, Ginkgo biloba, Echinacea, ginseng, velerian and phytoestrogens (excluding soy).

Note : Data incomplete Subject were consecutive breast cancer patients

หน้า 1

EN

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