ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : เมล็ด

Activity : DRUG INTERACTION

Solvent/Active Compound : daidzein

Type of experiment : human

Type of animal : -

Type of study : Single-blind trial

N(Total) : 20 (M/F = 10/10)

N(Treatment) : 10

Sex : Both sex

Age : 22-28 yrs. (mean 25)

Route : Oral administration

Dose/Conc.(herb) : 200 mg daidzein twice daily for 10 days and on day 12, the test group received 200 mg daidzein with 100 mg theophylline.

Duration : 10 days

Type of interaction : Pharmacokinetics

Interaction with drug : Theophylline*/Aminophylline

Dose/Conc.(drug) : -

Result : Positive

Remark : Result: Comparing the kinetics parameters of theophylline of day 1 (without co-medication) with those of day 12 (10-day daidzein), the AUC (0-48), AUC (0- infinity), C(max) and t(1/2) were significantly increased by 33.57+/-21.75% (Cl, 1.21-1.46, P<0.05), 33.77+/-21.45% (Cl, 1.20-1.46, P<0.05), 23.54+/-16.93% (Cl, 1.23-1.52, P<0.05) and 41.39+/-45.92% (t=-3.19, P=0.011), respectively. The pharmacokinetic parameters of theophylline within the placebo group showed no statistically significant difference (P >0.05).

Note : Type of study: A single-blind, placebo-controlled, parallel study

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