| Synonym |
| Thai / English name |
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : GenistineType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 50 mg/BWkgDuration : -Type of interaction : PharmacokineticsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) : 200 mg/BWkgResult : PositiveRemark : The activity of CYP2E1 was not significant difference between control and Gen 3 group. The APAP increased activity of CYP2E1 with substantially more than the control and Gen3 groups, and there was a significant change in APAP administered with or without genistein. Genistein suppressed the activities induced by APAP, exhibiting dose-dependent effects.Note : Mice were divided into six groups: the control group (untreated, control check), the reagent control group (Gen treatment at 200 mg/BWkg i.g., named as Gen3), the APAP group (200 mg/BWkg i.g.), the APAP (200 mg/BWkg i.g.) + Gen1 (50 mg/BWkg i.g.) group, the APAP + Gen2 (100 mg/BWkg i.g.) group and the APAP + Gen3 (200 mg/BWkg) group. Ten mice from every group were obtained blood and liver for 16 h after treatment.
Part Used : เมล็ดActivity : CYP2E1 INHIBITIONSolvent/Active Compound : GenistineType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 50 mg/BWkgDuration : -Type of interaction : PharmacokineticsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) : 200 mg/BWkgResult : PositiveRemark : The activity of CYP2E1 was not significant difference between control and Gen 3 group. The APAP increased activity of CYP2E1 with substantially more than the control and Gen3 groups, and there was a significant change in APAP administered with or without genistein. Genistein suppressed the activities induced by APAP, exhibiting dose-dependent effects.Note : Mice were divided into six groups: the control group (untreated, control check), the reagent control group (Gen treatment at 200 mg/BWkg i.g., named as Gen3), the APAP group (200 mg/BWkg i.g.), the APAP (200 mg/BWkg i.g.) + Gen1 (50 mg/BWkg i.g.) group, the APAP + Gen2 (100 mg/BWkg i.g.) group and the APAP + Gen3 (200 mg/BWkg) group. Ten mice from every group were obtained blood and liver for 16 h after treatment.
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : GenistineType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 100 mg/BWkgDuration : -Type of interaction : PharmacokineticsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) : 200 mg/BWkgResult : PositiveRemark : The activity of CYP2E1 was not significant difference between control and Gen 3 group. The APAP increased activity of CYP2E1 with substantially more than the control and Gen3 groups, and there was a significant change in APAP administered with or without genistein. Genistein suppressed the activities induced by APAP, exhibiting dose-dependent effects.Note : Mice were divided into six groups: the control group (untreated, control check), the reagent control group (Gen treatment at 200 mg/BWkg i.g., named as Gen3), the APAP group (200 mg/BWkg i.g.), the APAP (200 mg/BWkg i.g.) + Gen1 (50 mg/BWkg i.g.) group, the APAP + Gen2 (100 mg/BWkg i.g.) group and the APAP + Gen3 (200 mg/BWkg) group. Ten mice from every group were obtained blood and liver for 16 h after treatment.
Part Used : เมล็ดActivity : CYP2E1 INHIBITIONSolvent/Active Compound : GenistineType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 100 mg/BWkgDuration : -Type of interaction : PharmacokineticsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) : 200 mg/BWkgResult : PositiveRemark : The activity of CYP2E1 was not significant difference between control and Gen 3 group. The APAP increased activity of CYP2E1 with substantially more than the control and Gen3 groups, and there was a significant change in APAP administered with or without genistein. Genistein suppressed the activities induced by APAP, exhibiting dose-dependent effects.Note : Mice were divided into six groups: the control group (untreated, control check), the reagent control group (Gen treatment at 200 mg/BWkg i.g., named as Gen3), the APAP group (200 mg/BWkg i.g.), the APAP (200 mg/BWkg i.g.) + Gen1 (50 mg/BWkg i.g.) group, the APAP + Gen2 (100 mg/BWkg i.g.) group and the APAP + Gen3 (200 mg/BWkg) group. Ten mice from every group were obtained blood and liver for 16 h after treatment.
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : GenistineType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 200 mg/BWkgDuration : -Type of interaction : PharmacokineticsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) : 200 mg/BWkgResult : PositiveRemark : The activity of CYP2E1 was not significant difference between control and Gen 3 group. The APAP increased activity of CYP2E1 with substantially more than the control and Gen3 groups, and there was a significant change in APAP administered with or without genistein. Genistein suppressed the activities induced by APAP, exhibiting dose-dependent effects.Note : Mice were divided into six groups: the control group (untreated, control check), the reagent control group (Gen treatment at 200 mg/BWkg i.g., named as Gen3), the APAP group (200 mg/BWkg i.g.), the APAP (200 mg/BWkg i.g.) + Gen1 (50 mg/BWkg i.g.) group, the APAP + Gen2 (100 mg/BWkg i.g.) group and the APAP + Gen3 (200 mg/BWkg) group. Ten mice from every group were obtained blood and liver for 16 h after treatment.
Part Used : เมล็ดActivity : CYP2E1 INHIBITIONSolvent/Active Compound : GenistineType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 200 mg/BWkgDuration : -Type of interaction : PharmacokineticsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) : 200 mg/BWkgResult : PositiveRemark : The activity of CYP2E1 was not significant difference between control and Gen 3 group. The APAP increased activity of CYP2E1 with substantially more than the control and Gen3 groups, and there was a significant change in APAP administered with or without genistein. Genistein suppressed the activities induced by APAP, exhibiting dose-dependent effects.Note : Mice were divided into six groups: the control group (untreated, control check), the reagent control group (Gen treatment at 200 mg/BWkg i.g., named as Gen3), the APAP group (200 mg/BWkg i.g.), the APAP (200 mg/BWkg i.g.) + Gen1 (50 mg/BWkg i.g.) group, the APAP + Gen2 (100 mg/BWkg i.g.) group and the APAP + Gen3 (200 mg/BWkg) group. Ten mice from every group were obtained blood and liver for 16 h after treatment.
Part Used : เมล็ดActivity : UDP-GLUCURONYL TRANSFERASE STIMULATIONSolvent/Active Compound : GenistineType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 50 mg/BWkgDuration : -Type of interaction : PharmacokineticsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) : 200 mg/BWkgResult : PositiveRemark : The genistein enhanced significantly the activities of UGTs during acute liver injury induced by APAP, and the alterative activities of UGTs were in consonance with the rate of APAP glucuronidation. All the mRNA expressions of UGT1a1, 1a6, 1a10 and UGT2b1 in the model (treated with APAP) groups were much lower than in the control and APAP + Gen groups because of partial hepatocyte necrosis or death, but the level of mRNA expression in all the APAP + Gen groups were greatly enhanced.Note : Mice were divided into six groups: the control group (untreated, control check), the reagent control group (Gen treatment at 200 mg/BWkg i.g., named as Gen3), the APAP group (200 mg/BWkg i.g.), the APAP (200 mg/BWkg i.g.) + Gen1 (50 mg/BWkg i.g.) group, the APAP + Gen2 (100 mg/BWkg i.g.) group and the APAP + Gen3 (200 mg/BWkg) group. Ten mice from every group were obtained blood and liver for 16 h after treatment.
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : GenistineType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 50 mg/BWkgDuration : -Type of interaction : PharmacokineticsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) : 200 mg/BWkgResult : PositiveRemark : The genistein enhanced significantly the activities of UGTs during acute liver injury induced by APAP, and the alterative activities of UGTs were in consonance with the rate of APAP glucuronidation. All the mRNA expressions of UGT1a1, 1a6, 1a10 and UGT2b1 in the model (treated with APAP) groups were much lower than in the control and APAP + Gen groups because of partial hepatocyte necrosis or death, but the level of mRNA expression in all the APAP + Gen groups were greatly enhanced.Note : Mice were divided into six groups: the control group (untreated, control check), the reagent control group (Gen treatment at 200 mg/BWkg i.g., named as Gen3), the APAP group (200 mg/BWkg i.g.), the APAP (200 mg/BWkg i.g.) + Gen1 (50 mg/BWkg i.g.) group, the APAP + Gen2 (100 mg/BWkg i.g.) group and the APAP + Gen3 (200 mg/BWkg) group. Ten mice from every group were obtained blood and liver for 16 h after treatment.
Part Used : เมล็ดActivity : UDP-GLUCURONYL TRANSFERASE STIMULATIONSolvent/Active Compound : GenistineType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Sub-cutaneousDose/Conc.(herb) : 50 mg/BWkgDuration : -Type of interaction : PharmacokineticsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) : 200 mg/BWkgResult : PositiveRemark : The genistein enhanced significantly the activities of UGTs during acute liver injury induced by APAP, and the alterative activities of UGTs were in consonance with the rate of APAP glucuronidation. All the mRNA expressions of UGT1a1, 1a6, 1a10 and UGT2b1 in the model (treated with APAP) groups were much lower than in the control and APAP + Gen groups because of partial hepatocyte necrosis or death, but the level of mRNA expression in all the APAP + Gen groups were greatly enhanced.Note : Mice were divided into six groups: the control group (untreated, control check), the reagent control group (Gen treatment at 200 mg/BWkg i.g., named as Gen3), the APAP group (200 mg/BWkg i.g.), the APAP (200 mg/BWkg i.g.) + Gen1 (50 mg/BWkg i.g.) group, the APAP + Gen2 (100 mg/BWkg i.g.) group and the APAP + Gen3 (200 mg/BWkg) group. Ten mice from every group were obtained blood and liver for 16 h after treatment.
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : GenistineType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Sub-cutaneousDose/Conc.(herb) : 50 mg/BWkgDuration : -Type of interaction : PharmacokineticsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) : 200 mg/BWkgResult : PositiveRemark : The genistein enhanced significantly the activities of UGTs during acute liver injury induced by APAP, and the alterative activities of UGTs were in consonance with the rate of APAP glucuronidation. All the mRNA expressions of UGT1a1, 1a6, 1a10 and UGT2b1 in the model (treated with APAP) groups were much lower than in the control and APAP + Gen groups because of partial hepatocyte necrosis or death, but the level of mRNA expression in all the APAP + Gen groups were greatly enhanced.Note : Mice were divided into six groups: the control group (untreated, control check), the reagent control group (Gen treatment at 200 mg/BWkg i.g., named as Gen3), the APAP group (200 mg/BWkg i.g.), the APAP (200 mg/BWkg i.g.) + Gen1 (50 mg/BWkg i.g.) group, the APAP + Gen2 (100 mg/BWkg i.g.) group and the APAP + Gen3 (200 mg/BWkg) group. Ten mice from every group were obtained blood and liver for 16 h after treatment.
