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Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : p-coumaric acidType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0-100 micromolarDuration : 24-48 hoursType of interaction : PharmacodynamicsInteraction with drug : Thiazolidinedione*/2,4-thiazolidinedioneDose/Conc.(drug) : 0-100 micromolarResult : PositiveRemark : - Thiazolidinedione (20 micromolar) in combination with ferulic acid (25 micromolar), eugenol (50 micromolar), chlorogenic acid (25 micromolar), caffeic acid (25 micromolar), and p-coumaric acid (25 micromolar) increased 2DG uptake by 7-, 6.8-, 6.7-, 6.5-, and 6.34-fold, respectively, with respect to control. - All of the phytochemicals, except cinnamic acid, showed synergistic behavior with both the OHDs in the uptake of 2DG, whereas cinnamic acid exhibited an additive effect.Note : The effect of cinnamic acid, ferulic acid, p-coumaric acid, eugenol, chlorogenic acid, and caffeic acid, alone and in combination with two commercial oral hypoglycemic drugs (OHD), namely, thiazolidinedione (THZ) and metformin on the uptake of 2-deoxyglucose (2DG) by 3T3-L1 adipocytes is studied.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : p-coumaric acidType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0-100 micromolarDuration : 24-48 hoursType of interaction : PharmacodynamicsInteraction with drug : MetforminDose/Conc.(drug) : 0-100 micromolarResult : PositiveRemark : - Metformin (20 micromolar) with ferulic acid (25 micromolar), eugenol (25 micromolar), chlorogenic acid (25 micromolar), p-coumaric acid (25 micromolar), caffeic acid (25 micromolar), and cinnamic acid (25 micromolar) increased 2DG uptake by 6.5-, 6.4-, 6.2-, 6.1-, 6.3-, and 5.9-fold, respectively, when compared to control. - All of the phytochemicals, except cinnamic acid, showed synergistic behavior with both the OHDs in the uptake of 2DG, whereas cinnamic acid exhibited an additive effect.Note : The effect of cinnamic acid, ferulic acid, p-coumaric acid, eugenol, chlorogenic acid, and caffeic acid, alone and in combination with two commercial oral hypoglycemic drugs (OHD), namely, thiazolidinedione (THZ) and metformin on the uptake of 2-deoxyglucose (2DG) by 3T3-L1 adipocytes is studied.
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : Peanut extractType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 6 mg peanut extract + 15 microgram cholera toxin for 3 consecutive days/weekDuration : 3 weeksType of interaction : PharmacokineticsInteraction with drug : DiclofenacDose/Conc.(drug) : 1 mg/kgResult : PositiveRemark : Administration of diclofenac before peanut extract (PE) + cholera toxin (CT) expsosure resulted in significant increases of serum levels of PE-specific lgG1 and lgE. Furthermore, mMCP-1, a measure for mast cell degranulation in vivo, was enhanced by diclofenac upon an oral chanllenge with PE. When mice were treated with 0 or 25 mg/kg diclofenac and PE in the absence of CT, no PE- specific antibodied could be detected, indicating that diclofenac at this dose is not able to elicit an allergic response in the absence of the adjuvant CT.
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : Peanut extractType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 6 mg peanut extract + 15 microgram cholera toxin for 3 consecutive days/weekDuration : 3 weeksType of interaction : PharmacokineticsInteraction with drug : DiclofenacDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : Administration of diclofenac before peanut extract (PE) + cholera toxin (CT) expsosure resulted in significant increases of serum levels of PE-specific lgG1 and lgE. Furthermore, mMCP-1, a measure for mast cell degranulation in vivo, was enhanced by diclofenac upon an oral chanllenge with PE. When mice were treated with 0 or 25 mg/kg diclofenac and PE in the absence of CT, no PE- specific antibodied could be detected, indicating that diclofenac at this dose is not able to elicit an allergic response in the absence of the adjuvant CT.
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : Peanut extractType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 6 mg peanut extract + 15 microgram cholera toxin for 3 consecutive days/weekDuration : 3 weeksType of interaction : PharmacokineticsInteraction with drug : DiclofenacDose/Conc.(drug) : 25 mg/kgResult : PositiveRemark : Administration of diclofenac before peanut extract (PE) + cholera toxin (CT) expsosure resulted in significant increases of serum levels of PE-specific lgG1 and lgE. Furthermore, mMCP-1, a measure for mast cell degranulation in vivo, was enhanced by diclofenac upon an oral chanllenge with PE. When mice were treated with 0 or 25 mg/kg diclofenac and PE in the absence of CT, no PE- specific antibodied could be detected, indicating that diclofenac at this dose is not able to elicit an allergic response in the absence of the adjuvant CT.
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : Peanut extractType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 6 mg peanut extract for 3 consecutive/weekDuration : 3 weeksType of interaction : PharmacokineticsInteraction with drug : DiclofenacDose/Conc.(drug) : 1 mg/kgResult : NegativeRemark : Administration of diclofenac before peanut extract (PE) + cholera toxin (CT) expsosure resulted in significant increases of serum levels of PE-specific lgG1 and lgE. Furthermore, mMCP-1, a measure for mast cell degranulation in vivo, was enhanced by diclofenac upon an oral chanllenge with PE. When mice were treated with 0 or 25 mg/kg diclofenac and PE in the absence of CT, no PE- specific antibodied could be detected, indicating that diclofenac at this dose is not able to elicit an allergic response in the absence of the adjuvant CT.
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : Peanut extractType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 6 mg peanut extract for 3 consecutive/weekDuration : 3 weeksType of interaction : PharmacokineticsInteraction with drug : DiclofenacDose/Conc.(drug) : 10 mg/kgResult : NegativeRemark : Administration of diclofenac before peanut extract (PE) + cholera toxin (CT) expsosure resulted in significant increases of serum levels of PE-specific lgG1 and lgE. Furthermore, mMCP-1, a measure for mast cell degranulation in vivo, was enhanced by diclofenac upon an oral chanllenge with PE. When mice were treated with 0 or 25 mg/kg diclofenac and PE in the absence of CT, no PE- specific antibodied could be detected, indicating that diclofenac at this dose is not able to elicit an allergic response in the absence of the adjuvant CT.
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : Peanut extractType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 6 mg peanut extract for 3 consecutive days/weekDuration : 3 weeksType of interaction : PharmacokineticsInteraction with drug : DiclofenacDose/Conc.(drug) : 25 mg/kgResult : NegativeRemark : Administration of diclofenac before peanut extract (PE) + cholera toxin (CT) expsosure resulted in significant increases of serum levels of PE-specific lgG1 and lgE. Furthermore, mMCP-1, a measure for mast cell degranulation in vivo, was enhanced by diclofenac upon an oral chanllenge with PE. When mice were treated with 0 or 25 mg/kg diclofenac and PE in the absence of CT, no PE- specific antibodied could be detected, indicating that diclofenac at this dose is not able to elicit an allergic response in the absence of the adjuvant CT.
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : Peanut extractType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 1 mg peanut extractDuration : 3 daysType of interaction : PharmacokineticsInteraction with drug : DiclofenacDose/Conc.(drug) : 1 mg/kg, 2 h before each oral PE exposureResult : PositiveRemark : Administration of diclofenac before oral exposure to peanut extract (PE) did not abrogate oral tolerance induction, as PE-specific antibodies in serum were comparably low in diclofenac treated and vehicle-treated tolerized mice. In addition, cytokine levels in the supernatant of cultured splenocytes from PE-tolerized, diclofenac-treated mice were significantly lower compared with those in splenocyte cultures of non-tolerized mice. Noticeably, the ex vivo PE specific cytokine levels of diclofenac-treated tolerized mice were significantly higher compared with vehicle-treated tolerized mice, except in the case of lL-4.
