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| Thai / English name |
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : DeoxyelephantopinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.01-10 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : -Result : PositiveRemark : Deoxyelephantopin was also found to inhibit metabolism of midazolam weakly between 0.01 and 10 micromolar range of concentration (IC50 = 46.18 micromol). Deoxyelephantopin inhibited the metabolism of midazolam (>50%) at concentrations of 50 micromolar and above as compared with ketocozole, the inhibition was more pronounced, at concentrations 0.5 micromolar and above.
Part Used : ใบActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : DeoxyelephantopinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.01-10 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : -Result : PositiveRemark : Deoxyelephantopin was also found to inhibit metabolism of midazolam weakly between 0.01 and 10 micromolar range of concentration (IC50 = 46.18 micromolar). Deoxyelephantopin inhibited the metabolism of midazolam (>50%) at concentrations of 50 micromolar and above as compared with ketocozole, the inhibition was more pronounced, at concentrations 0.5 micromolar and above.
