ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ผล

Activity : CYP1A1 INHIBITION

Solvent/Active Compound : Piperlonguminine

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : 0-40 micromolar

Duration : -

Type of interaction : Pharmacokinetics

Interaction with drug : Phenacetin*/Acetophenetidin

Dose/Conc.(drug) : 20-80 micromolar

Result : Negative

Remark : Piperlonguminine (PL) only decreased CYP 1A2-catalyzed phenacetin O-deethylase activity with lC50 values of 10.0 micromolar, whereas the lC50 of PL on CYP1A1-actalyzed phenacetion O-deethylase activity was fivefold higher than the value of CYP1A2. Accordingly, PL was a specific substrate having inhibitiory effects on the CYP1A2 in HLMs, not CYP1A1.

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