Part Used : ใบ
Activity : ANTITUMOR ACTIVITY
Solvent/Active Compound : 70% methanol
Type of experiment : in vivo
Type of animal : mouse
N(Total) : -
N(Treatment) : -
Route : Intraperitoneal
Dose/Conc.(herb) : 10 mg/kg
Duration : 10 days
Type of interaction : P.Kinetics & P.Dynamics
Interaction with drug : Cyclophosphamide*/CPM/CTX/CYT
Dose/Conc.(drug) : 25 mg/kg
Remark : The combination of extract and CTX significantly reduced tumor volume (relative to in untreated hosts) by 73% compared to just by 52% when the extract alone was provided. Co-administration of the extract also mitigated CTX-induced toxicity, including decreases in WBC count, and in bone marrow cellularity and alpha-esterase activity. Extract treatment also attenuated any increases in serum levels of TNFalpha, iNOs, lL-1beta, lL-6, GM-CSF, and VEGF seen in tumor-bearing hosts.
Note : Type experiment: BALB/c mice was randomly allocated into seven groups.
Group l: normal control (treated with saline);
Group ll: cyclophosphamide (CTX) only (25 mg/kg, BW)
Group lll: 25 mg CTX/kg + 10 mg B. tomentosa extract/kg
Group IV: DAL tumor control (mice were to be treated with the Daltion ASCites Lymphoma (DAL) induced ascites and tumor formation)
Group V: DAL tumor + 25 mg CTX/kg
Group Vl: DAL tumor + 10 mg B. tomentosa extract/kg
Group Vlll: DAL tumor + 25 mg CTX/kg + 10 mg B. tomentosa extract/kg
