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Part Used : ไม่ระบุActivity : CYTOCHROME P450 LEVEL DECREASESolvent/Active Compound : catechinsType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.25% catechinDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The contents of cytochrome P450 contents in catechin free diet (MW-0C) group was increased to 95%, compared with normal group. 0.25% catechin (MW-0.25C) and 0.5% catechin (MW-0.5C) groups were reduced to 16% and 31%, resp., compared with MW-0C group.Note : Data incomplete
Part Used : ไม่ระบุActivity : CYTOCHROME P450 LEVEL DECREASESolvent/Active Compound : catechinsType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.5% catechinDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The contents of cytochrome P450 contents in catechin free diet (MW-0C) group was increased to 95%, compared with normal group. 0.25% catechin (MW-0.25C) and 0.5% catechin (MW-0.5C) groups were reduced to 16% and 31%, resp., compared with MW-0C group.Note : Data incomplete
Part Used : ไม่ระบุActivity : CYTOCHROME P450 LEVEL DECREASESolvent/Active Compound : catechinsType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 0.25% catechinDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Cytochrome P450 levels in the catechin-free (MW-0C) group was increased by 85% compared with normal, but was 11% and 14% lower in the 0.25% catechin (MW-0.25C) and 0.5% catechin (MW-0.5C) groups than in the MW-0C group. NADPH-cytochrome P450 reductase activity in the MW-0C group was increased by 29%, compared with the normal group, but was significantly less in the MW-0.25C and MW-0.5C groups.Note : Data incomplete
Part Used : ไม่ระบุActivity : CYTOCHROME P450 LEVEL DECREASESolvent/Active Compound : catechinsType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 0.5% catechinDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Cytochrome P450 levels in the catechin-free (MW-0C) group was increased by 85% compared with normal, but was 11% and 14% lower in the 0.25% catechin (MW-0.25C) and 0.5% catechin (MW-0.5C) groups than in the MW-0C group. NADPH-cytochrome P450 reductase activity in the MW-0C group was increased by 29%, compared with the normal group, but was significantly less in the MW-0.25C and MW-0.5C groups.Note : Data incomplete
Part Used : ไม่ระบุActivity : CYTOCHROME P450 LEVEL DECREASESolvent/Active Compound : -Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 2.5% decaffeinated black tea ext. (DBTE)Duration : 15 daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Treatment with 2.5% decaffeinated black tea ext. (DBTE) or 1% polymeric black tea polyphenol (PBP) mix did not significantly alter the basal activity and level of CYP1A1 and CYP1A2.Note : Data incomplete
Part Used : ไม่ระบุActivity : CYTOCHROME P450 LEVEL DECREASESolvent/Active Compound : polyphenolType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 1% polymeric black tea polyphenol (PBP)Duration : 15 daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Treatment with 2.5% decaffeinated black tea ext. (DBTE) or 1% polymeric black tea polyphenol (PBP) mix did not significantly alter the basal activity and level of CYP1A1 and CYP1A2.Note : Data incomplete
Part Used : ไม่ระบุActivity : CYTOCHROME P450 LEVEL DECREASESolvent/Active Compound :Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 2.5% decaffeinated black tea ext. (DBTE)Duration : 15 daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) :Result : PositiveRemark : Pretreatment with 2.5% decaffeinated black tea ext. (DBTE) or 1% polymeric black tea polyphenol (PBP) mix resulted in a significant decrease in both the activity and the level of B(a)P-induced CYP1A1 and CYP1A2 in liver and lungs.Note : Data incomplete
Part Used : ไม่ระบุActivity : CYTOCHROME P450 LEVEL DECREASESolvent/Active Compound : -Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 1% polymeric black tea polyphenol (PBP)Duration : 15 daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) :Result : NegativeRemark : Pretreatment with 2.5% decaffeinated black tea ext. (DBTE) or 1% polymeric black tea polyphenol (PBP) mix resulted in a significant decrease in both the activity and the level of B(a)P-induced CYP1A1 and CYP1A2 in liver and lungs.Note : Data incomplete
