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| Thai / English name |
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Green teaType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : PositiveRemark : Catechins inhibit some CYP enzymes and P-gp, but inhibition of CYP enzymes thought to be reason for chemoprotectant effect of tea. Caution with warfarin. Caffeine induces CYP1A2.Note : Data incomplete, data from review article.
Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : ferulic acid (FA)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : VancomycinDose/Conc.(drug) : -Result : PositiveRemark : FA interacts in a synergistic way with antibiotics such as amikacin, ampicillin, ciprofloxacin, erythromycin and vancomycin against Gram negative (Escherichia coli, Enterobacter aerogenes and Pseudomonas aeruginosa) and positive (Staphylococcus aureus) bacteria.Note : Data incomplete
Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : ferulic acid (FA)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : AmikacinDose/Conc.(drug) : -Result : PositiveRemark : FA interacts in a synergistic way with antibiotics such as amikacin, ampicillin, ciprofloxacin, erythromycin and vancomycin against Gram negative (Escherichia coli, Enterobacter aerogenes and Pseudomonas aeruginosa) and positive (Staphylococcus aureus) bacteria.Note : Data incomplete
Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : ferulic acid (FA)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : CiprofloxacinDose/Conc.(drug) : -Result : PositiveRemark : FA interacts in a synergistic way with antibiotics such as amikacin, ampicillin, ciprofloxacin, erythromycin and vancomycin against Gram negative (Escherichia coli, Enterobacter aerogenes and Pseudomonas aeruginosa) and positive (Staphylococcus aureus) bacteria.Note : Data incomplete
Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : ferulic acid (FA)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : Erythromycin*/ErythrocinDose/Conc.(drug) : -Result : PositiveRemark : FA interacts in a synergistic way with antibiotics such as amikacin, ampicillin, ciprofloxacin, erythromycin and vancomycin against Gram negative (Escherichia coli, Enterobacter aerogenes and Pseudomonas aeruginosa) and positive (Staphylococcus aureus) bacteria.Note : Data incomplete
Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : ferulic acid (FA)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : AmpicillinDose/Conc.(drug) : -Result : PositiveRemark : FA interacts in a synergistic way with antibiotics such as amikacin, ampicillin, ciprofloxacin, erythromycin and vancomycin against Gram negative (Escherichia coli, Enterobacter aerogenes and Pseudomonas aeruginosa) and positive (Staphylococcus aureus) bacteria.Note : Data incomplete
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Case reportN(Total) : 1N(Treatment) : 1Sex : FemaleAge : 42 yrsRoute : Oral administrationDose/Conc.(herb) : 1 g/ die of catechinsDuration : 10 daysType of interaction : PharmacokineticsInteraction with drug : IrbesartanDose/Conc.(drug) : 150 mg/dayResult : PositiveRemark : The patient, carrying genetic variant of hepatic metabolism making her particularly susceptible to oxidative stress, developed an abnormal response to a mild toxic insult, afforded by a combination of agents (oral contraceptives + irbesartan + green tea) that normally would not be able to cause damage. Her particular hepatic metabolism might have further increased the drugs' concentration, favoring the haptenization of liver proteins, eventually leading to the development of an autoimmune hepatitis.
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Case reportN(Total) : 1N(Treatment) : 1Sex : FemaleAge : 42 yrsRoute : Oral administrationDose/Conc.(herb) : 1 g/ die of catechinsDuration : 10 daysType of interaction : PharmacokineticsInteraction with drug : GestodeneDose/Conc.(drug) : -Result : PositiveRemark : The patient, carrying genetic variant of hepatic metabolism making her particularly susceptible to oxidative stress, developed an abnormal response to a mild toxic insult, afforded by a combination of agents (oral contraceptives + irbesartan + green tea) that normally would not be able to cause damage. Her particular hepatic metabolism might have further increased the drugs' concentration, favoring the haptenization of liver proteins, eventually leading to the development of an autoimmune hepatitis. *Interaction with a combination of gestodene and 17alpha-ethinylestradiol as oral contraceptive
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Case reportN(Total) : 1N(Treatment) : 1Sex : FemaleAge : 42 yrsRoute : Oral administrationDose/Conc.(herb) : 1 g/ die of catechinsDuration : 10 daysType of interaction : PharmacokineticsInteraction with drug : Estradiol*/17 alpha-ethinylestradiolDose/Conc.(drug) : -Result : PositiveRemark : The patient, carrying genetic variant of hepatic metabolism making her particularly susceptible to oxidative stress, developed an abnormal response to a mild toxic insult, afforded by a combination of agents (oral contraceptives + irbesartan + green tea) that normally would not be able to cause damage. Her particular hepatic metabolism might have further increased the drugs' concentration, favoring the haptenization of liver proteins, eventually leading to the development of an autoimmune hepatitis. *Interaction with a combination of gestodene and 17alpha-ethinylestradiol as oral contraceptive
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : green tea extract (GTE)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 400 mg/kgDuration : 30 min.*Type of interaction : PharmacokineticsInteraction with drug : Nadolol*/CorgardDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : - Pretreatment with GTE resulted in marked reductions in the maximum concentration (Cmax) and area under the time-plasma concentration curve (AUC) of nadolol by 85% and 74%, respectively, as compared with control. In addition, EGCG alone significantly reduced Cmax and AUC of nadolol. Amounts of nadolol excreted into the urine were decreased by pretreatments with GTE and EGCG, while the terminal half-life on nadolol was not different among groups.Note : Duration: *Rats received green tea extract (GTE) and (-)-epigallocatechin-3-gallate (EGCG) or saline (control) by oral gavage, 30 min before a single intragastric administratiion of nadolol. - These results suggest that the coadministration with green tea catechins, particularly EGCG, causes a significant alteration in the pharmacokinetics of nadolol.
