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Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : green tea extract (GTE)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 400 mg/kgDuration : 30 min.*Type of interaction : PharmacokineticsInteraction with drug : Nadolol*/CorgardDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : - Pretreatment with GTE resulted in marked reductions in the maximum concentration (Cmax) and area under the time-plasma concentration curve (AUC) of nadolol by 85% and 74%, respectively, as compared with control. In addition, EGCG alone significantly reduced Cmax and AUC of nadolol. Amounts of nadolol excreted into the urine were decreased by pretreatments with GTE and EGCG, while the terminal half-life on nadolol was not different among groups.Note : Duration: *Rats received green tea extract (GTE) and (-)-epigallocatechin-3-gallate (EGCG) or saline (control) by oral gavage, 30 min before a single intragastric administratiion of nadolol. - These results suggest that the coadministration with green tea catechins, particularly EGCG, causes a significant alteration in the pharmacokinetics of nadolol.
Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : (-)-epigallocatechin-3-gallate (EGCG)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 150 mg/kgDuration : 30 min.*Type of interaction : PharmacokineticsInteraction with drug : Nadolol*/CorgardDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : - Pretreatment with GTE resulted in marked reductions in the maximum concentration (Cmax) and area under the time-plasma concentration curve (AUC) of nadolol by 85% and 74%, respectively, as compared with control. In addition, EGCG alone significantly reduced Cmax and AUC of nadolol. Amounts of nadolol excreted into the urine were decreased by pretreatments with GTE and EGCG, while the terminal half-life on nadolol was not different among groups.Note : Duration: *Rats received green tea extract (GTE) and (-)-epigallocatechin-3-gallate (EGCG) or saline (control) by oral gavage, 30 min before a single intragastric administratiion of nadolol. - These results suggest that the coadministration with green tea catechins, particularly EGCG, causes a significant alteration in the pharmacokinetics of nadolol.
Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : decaffeinated green teaType of experiment : humanType of animal : -Type of study : Open trialN(Total) : 11N(Treatment) : 11Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 4 DGT capsules/day (DGT capsule contained 211+/-25 mg of green tea catechins and <1 mg of caffeine)Duration : 14 daysType of interaction : PharmacokineticsInteraction with drug : AlprazolamDose/Conc.(drug) : 2 mgResult : NegativeRemark : There were no significant differences in ALPZ pharmacokinetics at baseline and after DGT treatment (all P values >/=0.05; max. concn. in plasma, 33+/-8 vs. 34+/-13 ng/mL; time to reach max. concn. in plasma, 1.4+/-1.2 vs. 1.4+/-1.2 h; area under the plasma concn. vs. time curve, 480+/-119 vs. 510 +/- 107 h-ng-ml-1; half-life of elimination, 12.3+/-1.7 vs. 13.1+/-3.4 h).Note : Data incomplete Subject total: healthy volunteers - Results indicate that DGT is unlikely to alter the disposition of medications primarity dependent on the CYP2D6 or CYP3A4 pathways of metabolism. Abbreviation decaffeinated green tea : DGT dextromethorphan metabolic ratios: DMRS alprazola: ALPZ
Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : 1 weeksType of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : -Result : PositiveRemark : Although single treatments with green tea exts. or grape seed ext. had negligible effects, 1 wk of treatment with them resulted in a significant increase in the ke of i.v. administered midazolam (MDZ), indicating the induction of CYP3A in the liver.Note : Data incomplete
Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : green tea extractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 175 mg kg-1Duration : 4 daysType of interaction : PharmacokineticsInteraction with drug : ClozapineDose/Conc.(drug) : 20 mg kg-1Result : EquivocalRemark : There was no significant difference in the elimination half-life of clozapine between the green tea ext. and saline groups. However, the time to reach peak concn. (Tmax) was significantly increased by green tea ext. The mean total area under the plasma concn.-time curve (AUC0-infinity) and maximal peak plasma concn. (Cmax) of clozapine in the green tea ext. group were significantly lower than those of controls.Note : Data incomplete
Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Open trialN(Total) :N(Treatment) :Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 0.3 g ext./250 mLDuration : -Type of interaction : PharmacokineticsInteraction with drug : Folic acid*/Folate/Pteroylglutamic acid/Vitamin M/FolacidDose/Conc.(drug) : 0.4 mgResult : PositiveRemark : At the 0.4 mg folic acid dose, green and black tea reduced the mean Cmax of serum folate by 39.2% and 38.6%, and the mean AUCo-infinity by 26.6% and 17.9%, resp.Note : Data incomplete Subjects: healthy volunteers - The present results suggest an in vivo interaction between tea and folic acid with even low concns. of green and black tea exts. yielding decreased bioavailabilites of folic acid.
Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) :N(Treatment) :Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 0.3 g ext./250 mLDuration : -Type of interaction : PharmacokineticsInteraction with drug : Folic acid*/Folate/Pteroylglutamic acid/Vitamin M/FolacidDose/Conc.(drug) : 0.4 mgResult : PositiveRemark : At the 0.4 mg folic acid dose, green and black tea reduced the mean Cmax of serum folate by 39.2% and 38.6%, and the mean AUCo-infinity by 26.6% and 17.9%, resp.Note : Data incomplete Subjects: healthy volunteers - The present results suggest an in vivo interaction between tea and folic acid with even low concns. of green and black tea exts. yielding decreased bioavailabilites of folic acid.
Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Open trialN(Total) :N(Treatment) :Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 0.3 g ext./250 mLDuration : -Type of interaction : PharmacokineticsInteraction with drug : Folic acid*/Folate/Pteroylglutamic acid/Vitamin M/FolacidDose/Conc.(drug) : 5 mgResult : PositiveRemark : At the 5 mg folic acid dose, the mean Cmax of serum folate was reduced by 27.4% and the mean AUCo-infinity was decreased significantly by 39.9% by the co-application of green tea.Note : Data incomplete Subjects: healthy volunteers - The present results suggest an in vivo interaction between tea and folic acid with even low concns. of green and black tea exts. yielding decreased bioavailabilites of folic acid.
Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) :N(Treatment) :Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 0.3 g ext./250 mLDuration : -Type of interaction : PharmacokineticsInteraction with drug : Folic acid*/Folate/Pteroylglutamic acid/Vitamin M/FolacidDose/Conc.(drug) : 5 mgResult : PositiveRemark : At the 5 mg folic acid dose, the mean Cmax of serum folate was reduced by 27.4% and the mean AUCo-infinity was decreased significantly by 39.9% by the co-application of green tea.Note : Data incomplete Subjects: healthy volunteers - The present results suggest an in vivo interaction between tea and folic acid with even low concns. of green and black tea exts. yielding decreased bioavailabilites of folic acid.
Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : polyphenols (TP)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : OtherDose/Conc.(herb) : TP400 mg.kg-1Duration : 14 daysType of interaction : PharmacokineticsInteraction with drug : LansoprazoleDose/Conc.(drug) : 8 mg.kg-1Result : PositiveRemark : Route: Intragastrically - The pharmacokinetic parameters showed that TP decreased the AUC (0-4), Cmax and t1/2z remarkably, increased the AUC (0-4) ratios of 5-hydroxylansoprazole to lansoprazole sulfone significantly (P<0.05), while showed no significant influence on the pharmacokinetics of lansoprazole sulfone (P>0.05). TP could decrease the bioavailability of lansoprazole in rats significantly, which was probably related to the induction of CYP2C19 by TP.Note : Data incomplete
