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THEACEAE Camellia sinensis (L.) Kuntze

Synonym

THEACEAE Thea sinensis L.
THEACEAE Camellia sinensis (L.) Kuntze var. assamica (Mast.) Kitam.

Thai / English name

ชา*

[1-3] of 3 article(s) found

หน้า 1

[1] INTERACTIONS BETWEEN HERBAL AND CONVENTIONAL MEDICINES: THE ROLE OF CYTOCHROME P450 ENZYMES AND P-GLYCOPROTEIN.
WILLIAMSON EM
PHARMACOLOGYONLINE 2006 Vol.2(),200-5 $29296 [Full]

Part Used : ไม่ระบุ
Activity : P-GLYCOPROTEIN INHIBITION

Solvent/Active Compound : Green tea

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Warfarin
Dose/Conc.(drug) : -

Result : Positive

Remark : Catechins inhibit some CYP enzymes and P-gp, but inhibition of CYP enzymes thought to be reason for chemoprotectant effect of tea. Caution with warfarin. Caffeine induces CYP1A2.

Note : Data incomplete, data from review article.

[2] INTERACTIONS BETWEEN HERBAL AND CONVENTIONAL MEDICINES: THE ROLE OF CYTOCHROME P450 ENZYMES AND P-GLYCOPROTEIN.
WILLIAMSON EM
PHARMACOLOGYONLINE 2006 Vol.(2),200-5 $56391 [Full]

Part Used : ไม่ระบุ
Activity : P-GLYCOPROTEIN INHIBITION

Solvent/Active Compound : catechins

Type of experiment : non specified
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : None reported. Catechins inhibit some CYP enzyme and P-gp, but inhibition of CYP enzymes thought to be reason for chemoprotectant effect of tea. Caution with warfarin. Caffeine induces CYP1A2.

Note : Data from review, data incomplete.

[3] ENHANCING ACTIVITY OF ANTICANCER DRUGS IN MULTIDRUG RESISTANT TUMORS BY MODULATING P-GLYCOPROTEIN THROUGH DIETARY NUTRACEUTICALS.
MUHAMMAD KHAN,AMARA MARYAM,TAHIR MEHMOOD,ET AL.
ASIAN PAC J CANCER PREV 2015 Vol.16(16),6831-9 $59875 [Full]

Part Used : ใบ
Activity : P-GLYCOPROTEIN INHIBITION

Solvent/Active Compound : Epigallocatechin gallate (EGCG)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Doxorubicin*/Adrimycin/ADR/Adria
Dose/Conc.(drug) : -

Result : Positive

Remark : EGCG exerts reversal effect on MDR through modulation of p-glycoprotein transport activity rather than inhibition of p-glycoprotein expression.

Note : Data from review

หน้า 1

EN

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