Remark : Type of experiment: mouse xenograft model
Results: Mice treated with both green tea and tamoxifen had the smallest MCF-7 xenograft tumor size, and the highest levels of apoptosis in tumor tissue, as compared with either agent administered alone. moreover, the suppression of angiogenesis in vivo correlated with larger areas of necrosis and lower tumor blood vessel density in treated xenografts. The combination of green tea and tamoxifen significantly reduced the levels of estrogen receptor (ER)-alpha, in comparison to either agent alone.