Part Used : -
Activity : INSULIN-LIKE GROWTH FACTOR 1 INHIBITION
Solvent/Active Compound : green tea polyphenols
Type of experiment : in vivo
Type of animal : mouse
N(Total) : -
N(Treatment) : -
Route : Oral administration
Dose/Conc.(herb) : 0.1% in drinking water
Duration : -
Type of interaction : P.Kinetics & P.Dynamics
Interaction with drug : Celecoxib
Dose/Conc.(drug) : 5 mg/kg, i.p., daily, 5 days per weeks
Remark : Type of animal: nude mice
Results: Combination treatment with green tea polyphenols and celecoxib resulted in enhanced (a) tumor growth inhibition, (b) lowering of prostate-specific antigen levels, (c) lowering of insulin-like growth factor-l levels, and (d) circulating levels of serum insulin-like growth factor binding protein-3 compared with results of single-agent treatment.