ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : -

Activity : PEROXISOME PROLIFERATOR - ACTIVATED RECEPTOR (PPAR) INHIBITION

Solvent/Active Compound : (-)epigallocatechin-3-gallate (EGCG)

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : 10-40 micromolar/L

Duration : -

Type of interaction : P.Kinetics & P.Dynamics

Interaction with drug : NS-398

Dose/Conc.(drug) : 10 micromolar/L

Result : Positive

Remark : Type of experiment: human prostate cancer cells LNCaP, PC-3, and CWR22Rn1 Results: Combination of EGCG and NS-398 resulted in enhanced (a) cell growth inhibition; (b) apoptosis induction; (c) expression of Bax, pro-caspase-6, and pro-caspase-9, and poly (ADP) ribose polymerase cleavage; (d) inhibition of peroxisome proliferator activated receptor g; and (e) inhibition of nuclear factor-kB compared with the additive effects of the two agents alone, suggesting a possible synergism.

Note : Data incomplete

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