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THEACEAE Camellia sinensis (L.) Kuntze

Synonym

THEACEAE Thea sinensis L.
THEACEAE Camellia sinensis (L.) Kuntze var. assamica (Mast.) Kitam.

Thai / English name

ชา*

[1-3] of 3 article(s) found

หน้า 1

[1] EFFECT OF POLYMERIC BLACK TEA POLYPHENOLS ON BENZO(A)PYRENE [B(A)P]-INDUCED CYTOCHROME P4501A1 AND 1A2 IN MICE.
KRISHNAN R,RAGHUNATHAN R,MARU GB
XENOBIOTICA 2005 Vol.35(7),671-82 300387 [Abstract]

Part Used : ไม่ระบุ
Activity : CYP1A1 INHIBITION

Solvent/Active Compound : -

Type of experiment : in vivo
Type of animal : mouse

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : 2.5% decaffeinated black tea ext. (DBTE)

Duration : 15 days
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Treatment with 2.5% decaffeinated black tea ext. (DBTE) or 1% polymeric black tea polyphenol (PBP) mix did not significantly alter the basal activity and level of CYP1A1 and CYP1A2.

Note : Data incomplete

Part Used : ไม่ระบุ
Activity : CYP1A1 INHIBITION

Solvent/Active Compound : polyphenol

Type of experiment : in vivo
Type of animal : mouse

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : 1% polymeric black tea polyphenol (PBP)

Duration : 15 days
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Treatment with 2.5% decaffeinated black tea ext. (DBTE) or 1% polymeric black tea polyphenol (PBP) mix did not significantly alter the basal activity and level of CYP1A1 and CYP1A2.

Note : Data incomplete

Part Used : ไม่ระบุ
Activity : CYP1A1 INHIBITION

Solvent/Active Compound :

Type of experiment : in vivo
Type of animal : mouse

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : 2.5% decaffeinated black tea ext. (DBTE)

Duration : 15 days
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) :

Result : Positive

Remark : Pretreatment with 2.5% decaffeinated black tea ext. (DBTE) or 1% polymeric black tea polyphenol (PBP) mix resulted in a significant decrease in both the activity and the level of B(a)P-induced CYP1A1 and CYP1A2 in liver and lungs.

Note : Data incomplete

Part Used : ไม่ระบุ
Activity : CYP1A1 INHIBITION

Solvent/Active Compound : -

Type of experiment : in vivo
Type of animal : mouse

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : 1% polymeric black tea polyphenol (PBP)

Duration : 15 days
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) :

Result : Negative

Remark : Pretreatment with 2.5% decaffeinated black tea ext. (DBTE) or 1% polymeric black tea polyphenol (PBP) mix resulted in a significant decrease in both the activity and the level of B(a)P-induced CYP1A1 and CYP1A2 in liver and lungs.

Note : Data incomplete

[2] PROTECTIVE EFFECTS OF TEA MELANIN AGAINST 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN-INDUCED TOXICITY: ANTIOXIDANT ACTIVITY AND ARYL HYDROCARBON RECEPTOR SUPPRESSIVE EFFECT.
HUNG Y-C,HUANG GS,SAVA VM,ET AL.
BIOL PHARM BULL 2006 Vol.29(11),2284-91 340171 [Abstract]

Part Used : -
Activity : CYP1A1 INHIBITION

Solvent/Active Compound : tea melanin

Type of experiment : in vivo
Type of animal : mouse

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : 40 mg/kg

Duration : 14 days
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Both reduced tea melanin and non-reduced tea melanin suppressed the expression of CYP1A1 gene and prevented the activation of cytochrome P 450 isoenzyme in the livers of animals exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Note : Data incomplete

[3] PRETREATMENT WITH BLACK TEA POLYPHENOLS MODULATES XENOBIOTIC-METABOLIZING ENZYMES IN AN EXPERIMENTAL ORAL CARCINOGENESIS MODEL.
LETCHOUMY PV,MOHAN KVPC,STEGEMAN JJ,ET AL.
ONCOL RES 2008 Vol.17(2),75-85 416740 [Abstract]

Part Used : ใบ
Activity : CYP1A1 INHIBITION

Solvent/Active Compound : Black tea polyphenol

Type of experiment : in vivo
Type of animal : other

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : -

Duration : 4 weeks before carcinogen administration
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Administration of polyphenon-B significantly decreased tumor incident, oxidative DNA damage, phase I enzymes (CYP450; CYP1A1, 1A2 and 2B isoforms and cytochrome b5) as well as expression of CYP1A1 and CYP1B1 isoforms.

Note : Data incomplete. Type of animal = hamster

Part Used : ใบ
Activity : CYP1A1 INHIBITION

Solvent/Active Compound : Black tea polyphenol

Type of experiment : in vivo
Type of animal : other

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : -

Duration : 4 weeks after carcinogen administration
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Administration of BTF-35 significantly decreased tumor incident, oxidative DNA damage, phase I enzymes (CYP450; CYP1A1, 1A2 and 2B isoforms and cytochrome b5) as well as expression of CYP1A1 and CYP1B1 isoforms.

Note : Data incomplete. Type of animal = hamster

หน้า 1

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